Current Osteoporosis Reports

, Volume 1, Issue 2, pp 53–58

Role of cytokines in postmenopausal bone loss

  • Johannes Pfeilschifter

DOI: 10.1007/s11914-003-0009-4

Cite this article as:
Pfeilschifter, J. Curr Osteoporos Rep (2003) 1: 53. doi:10.1007/s11914-003-0009-4


It is increasingly recognized that changes in cytokine activity are involved in the pathophysiology of postmenopausal bone loss in many ways. Estrogen may affect skeletal cytokine activity by diverse mechanisms such as direct interference with cytokine gene transcription, regulation of major signaling molecules, changes in lymphocyte function, and central effects on the hypothalamic-pituitary-adrenal axis. This article summarizes our current knowledge of these interactions and discusses the possible implications with respect to the prevention and treatment of postmenopausal osteoporosis.

Copyright information

© Current Science Inc 2003

Authors and Affiliations

  • Johannes Pfeilschifter
    • 1
  1. 1.Berufsgenossenschaftliche Kliniken Bergmannsheil, Department of MedicineUniversity of BochumBochumGermany