Current Oncology Reports

, Volume 15, Issue 2, pp 146–151

Adjuvant Therapy in Gastric Cancer: What Is The Optimal Approach?

  • Takashi Taketa
  • Kazuki Sudo
  • Roopma Wadhawa
  • Mariela M. Blum
  • Jaffer A. Ajani
Gastrointestinal Cancers (BG Czito, Section Editor)

DOI: 10.1007/s11912-013-0298-4

Cite this article as:
Taketa, T., Sudo, K., Wadhawa, R. et al. Curr Oncol Rep (2013) 15: 146. doi:10.1007/s11912-013-0298-4
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Abstract

Gastric cancer confers a poor prognosis even when diagnosed as localized disease. Multimodality therapy improves the cure rate of patients with localized cancer. However, adjunctive therapeutic approaches differ in different regions of the world. This review focuses on the current standards and unresolved issues based on updated literature on therapy for localized gastric cancer. In the USA, the Intergroup 0116 trial established the use of postoperative chemoradiotherapy as a standard for patients who have surgery first for treatment of gastric cancer. In Europe, the MAGIC trial investigating perioperative chemotherapy demonstrated a survival benefit for gastric cancer patients. Finally, in Asia, the ACTS-GC and CLASSIC trials investigating postoperative chemotherapy established this as the standard of care after primary surgery that included D2 dissection. It is clear, however, that surgery alone is insufficient to achieve the highest possible cure rates.

Keywords

Gastric cancer Adjuvant therapy Preoperative Postoperative Biomarker 

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Takashi Taketa
    • 1
  • Kazuki Sudo
    • 1
  • Roopma Wadhawa
    • 1
  • Mariela M. Blum
    • 1
  • Jaffer A. Ajani
    • 1
  1. 1.Department of Gastrointestinal Medical OncologyThe University of Texas MD Anderson Cancer CenterHoustonUSA

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