Leukemia (A Aguayo, Section Editor)

Current Oncology Reports

, Volume 14, Issue 5, pp 359-368

Acute Myeloid Leukemia with Normal Cytogenetics

  • Raya MawadAffiliated withClinical Research Division, Fred Hutchinson Cancer Research CenterDepartment of Medicine, Division of Medical Oncology, University of Washington
  • , Elihu H. EsteyAffiliated withClinical Research Division, Fred Hutchinson Cancer Research CenterDepartment of Medicine, Division of Medical Oncology, University of Washington Email author 

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Abstract

Acute myeloid leukemia (AML) is proving to be a heterogeneous disease process that is driven by various genetic mutations and aberrant protein expression. As our population ages, the incidence of AML is likely to increase, with approximately a third of adult cases categorized with normal cytogenetics. Advances in technology are now allowing us to explore the genetic expression and protein transcription patterns of AML, providing more information that must find its place in the prognosis and the therapeutic algorithm of this disease. As we learn more, we hope to further categorize patients with normal karyotype AML into discrete risk categories that will help in treatment decision making and further elucidate the necessity for hematopoietic cell transplantation. However, at this time, many of the identified mutations and expression patterns are still experimental, requiring further analysis to determine their exact role in AML.

Keywords

Acute myeloid leukemia AML Normal cytogenetics Normal karyotype Intermediate risk