Current Oncology Reports

, Volume 14, Issue 3, pp 240–248

Renal Cell Carcinoma Deep Sequencing: Recent Developments

Genitourinary Cancers (E Jonasch, Section Editor)

DOI: 10.1007/s11912-012-0230-3

Cite this article as:
Farber, L.J., Furge, K. & Teh, B.T. Curr Oncol Rep (2012) 14: 240. doi:10.1007/s11912-012-0230-3

Abstract

Renal cell carcinoma (RCC) is the most common type of renal cancer in adults. RCC is notoriously resistant to current therapies suggesting the need to improve our knowledge and create more effective therapies. The molecular genetic defects that occur in RCC are extensive and complex ranging from single DNA changes, to large chromosomal defects, to signature disruptions in the transcription of hundreds of genes. These changes are often shared within each histological RCC subtype, illustrating their significance to the disease phenotype. This review presents an overview of the genetic abnormalities that occur within the most common subtypes of RCC. We discuss the recent molecular findings that have advanced our understanding of the somatic architecture of renal tumors and their impact on disease therapeutics.

Keywords

Amplification Chromophobe RCC Chromosome Clear cell RCC (ccRCC) Cytogenetic Deletion Exome Gene Gene expression Hypoxia-inducible factor (HIF) Mutation Oncocytoma Papillary RCC Renal Renal cell carcinoma (RCC) Sequence Sporadic Subtypes Tumor Von Hippel Lindau (VHL) Genitourinary cancers 

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.HollywoodUSA
  2. 2.NCCS-VARI Translational Research Laboratory, National Cancer Center, and Duke-NUS Graduate Medical SchoolSingaporeSingapore
  3. 3.Laboratory of Computational BiologyVan Andel Research InstituteGrand RapidsUSA