Article

Current Oncology Reports

, Volume 13, Issue 3, pp 157-167

Update: Modern Approaches to the Treatment of Localized Esophageal Cancer

  • James WelshAffiliated withDivision of Radiation Oncology, Unit 97, The University of Texas M.D. Anderson Cancer Center Email author 
  • , Arya AminiAffiliated withUniversity of California, Irvine
  • , Anna LikhachevaAffiliated withDivision of Radiation Oncology, Unit 97, The University of Texas M.D. Anderson Cancer Center
  • , Jeremy Erasmus J.Affiliated withDepartment of Diagnostic Radiology, Unit 1478, The University of Texas M.D. Anderson Cancer Center
  • , Daniel GomezAffiliated withDepartment of Radiation Oncology, Unit 1150, The University of Texas M.D. Anderson Cancer Center
  • , Marta DavilaAffiliated withDepartment of Gastroenterology, Hepatology, and Nutrition, Unit 1466, The University of Texas M.D. Anderson Cancer Center
  • , Reza J. MehranAffiliated withDepartment of Thoracic and Cardiovascular Surgery, Unit 1489, The University of Texas M.D. Anderson Cancer Center
  • , Ritsuko KomakiAffiliated withDivision of Radiation Oncology, Unit 97, The University of Texas M.D. Anderson Cancer Center
  • , Zhongxing LiaoAffiliated withDivision of Radiation Oncology, Unit 97, The University of Texas M.D. Anderson Cancer Center
    • , Wayne L. HofstetterAffiliated withDepartment of Thoracic and Cardiovascular Surgery, Unit 1489, The University of Texas M.D. Anderson Cancer Center
    • , Jeffrey Lee H.Affiliated withDepartment of Gastroenterology, Hepatology, and Nutrition, Unit 1466, The University of Texas M.D. Anderson Cancer Center
    • , Manoop S. BhutaniAffiliated withDepartment of Gastroenterology, Hepatology, and Nutrition, Unit 1466, The University of Texas M.D. Anderson Cancer Center
    • , Jaffer A. AjaniAffiliated withDepartment of Gastrointestinal Medical Oncology, Unit 426, The University of Texas M.D. Anderson Cancer Center

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Abstract

The optimal treatment strategy for esophageal cancer continues to be a topic of debate. Improvements in chemotherapy drugs, surgical techniques, and radiotherapy planning and delivery have led to the design of treatment approaches that are specific to both the stage of the tumor and the overall performance status of the patient. Surgery continues to be the standard treatment option for localized disease, but multimodality treatments that include radiation and chemotherapy with surgery are increasingly used. The next few years will continue to see improvements in radiation techniques, especially proton beam treatment; the development of additional minimally invasive surgical approaches to minimize postoperative side effects; and the discovery of molecular biomarkers to help specifically target treatment of esophageal cancer in individual patients.

Keywords

Esophageal cancer Diagnosis Minimally invasive treatments Chemoradiation Intensity-modulated radiation therapy Photon therapy Proton beam therapy