Current Oncology Reports

, Volume 12, Issue 2, pp 115-120

First online:

Human Papillomavirus: Changing Paradigms in Oropharyngeal Cancer

  • David J. AdelsteinAffiliated withDepartment of Solid Tumor Oncology, Cleveland Clinic Taussig Cancer Institute Email author 
  • , Cristina P. RodriguezAffiliated withDepartment of Solid Tumor Oncology, Cleveland Clinic Taussig Cancer Institute

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The human papillomavirus (HPV) has recently been identified as an important etiologic agent in the development of squamous cell carcinoma of the oropharynx. The HPV- associated cancers appear to have a different biology than the HPV-negative cancers, and affect a population that is more likely to be young, male, Caucasian, and nonsmoking. More importantly, however, is the recognition that patients with an HPV-associated oropharyngeal cancer have a distinctly better survival after treatment than those patients with HPV-negative tumors, although their prognosis is significantly worse if there is a history of tobacco abuse. HPV-associated oropharynx cancer should be recognized as a new biologic entity and studied separately from HPV-negative cancers in future clinical trials. The potential for disease prevention with the use of the current HPV vaccines is discussed.


Human papillomavirus Oropharynx cancer Head and neck cancer