Current Oncology Reports

, Volume 8, Issue 2, pp 146–154

Oral premalignancy: New methods of detection and treatment

  • Ann Gillenwater
  • Vali Papadimitrakopoulou
  • Rebecca Richards-Kortum

DOI: 10.1007/s11912-006-0050-4

Cite this article as:
Gillenwater, A., Papadimitrakopoulou, V. & Richards-Kortum, R. Curr Oncol Rep (2006) 8: 146. doi:10.1007/s11912-006-0050-4


Oral carcinogenesis proceeds through a stepwise accumulation of genetic damage over time. Because the oral cavity is easy to examine and risk factors for oral cancer are known, there is great opportunity to improve patient outcomes through diagnosis and treatment of premalignant lesions before the development of invasive oral carcinoma. This review provides a summary of developments in detection and diagnosis of oral premalignant lesions and innovative approaches to management of early oral neoplasia. These technological and therapeutic advances are much needed to improve the poor outcomes associated with oral cancer due to our inability to diagnose and treat this disease at an early, curable stage.

Copyright information

© Current Science Inc 2006

Authors and Affiliations

  • Ann Gillenwater
    • 1
  • Vali Papadimitrakopoulou
  • Rebecca Richards-Kortum
  1. 1.Department of Head and Neck Surgery, Unit 441The University of Texas M.D. Anderson Cancer CenterHoustonUSA