Current Oncology Reports

, Volume 2, Issue 2, pp 199–204

Epstein-Barr virus and hodgkin’s disease

  • Lawrence M. Weiss

DOI: 10.1007/s11912-000-0094-9

Cite this article as:
Weiss, L.M. Curr Oncol Rep (2000) 2: 199. doi:10.1007/s11912-000-0094-9


Approximately 40% to 50% of cases of Hodgkin’s disease occurring in Western populations are associated with the Epstein-Barr virus (EBV). In these cases, EBV is found in the neoplastic elements, the Reed-Sternberg and Hodgkin’s cells. EBV is probably not present in all cases, but neither have any other viruses been found in the cases that are EBV-negative. EBV may play a role in the pathogenesis of Hodgkin’s disease by the activation of anti-apoptotic factors in a premalignant germinal center B-lymphocyte. Regardless of their role in etiology or pathogenesis, EBV-latent antigens may represent a target for possible immune therapy.

Copyright information

© Current Science Inc 2000

Authors and Affiliations

  • Lawrence M. Weiss
    • 1
  1. 1.City of Hope National Medical CenterDuarteUSA

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