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Neurologic Manifestations of Gastrointestinal and Liver Diseases

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Abstract

Hepatic and gastrointestinal disorders can produce a wide spectrum of neurologic complications both affecting the central nervous system (CNS) and the peripheral nervous system. These manifestations range in severity from coma in acute liver failure and acute pancreatitis, to minor cognitive changes in chronic portosystemic encephalopathy and hepatitis C. Cerebrovascular diseases can complicate hepatitis C infection and inflammatory bowel disease. Demyelinating disorders may co-exist with inflammatory bowel disease. Anti-tumor necrosis factor alpha drugs may induce demyelination. Ataxia may occur in malabsorption syndromes and in gluten related disorders. Characteristic movement disorders are key features of acquired hepatocerebral degeneration and of Whipple disease. Multiple types of neuropathy can be found in association with hepatitis, inflammatory bowel disease and gluten related disorders.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance

  1. Bernal W, Wendon J. Acute liver failure. N Engl J Med. 2013;369:2525–34.

    Article  PubMed  CAS  Google Scholar 

  2. Datar S, Wijdicks EF. Neurologic manifestations of acute liver failure. Handb Clin Neurol. 2014;120:645–59.

    Article  PubMed  Google Scholar 

  3. Scott TR, Kronsten VT, Hughes RD, Shawcross DL. Pathophysiology of cerebral oedema in acute liver failure. World J Gastroenterol. 2013;19:9240–55. A comprehensive basic science review of the pathophysiology of liver failure and hepatic encephalopathy.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  4. Weissenborn K. Portosystemic encephalopathy. Handb Clin Neurol. 2014;120:661–74.

    Article  PubMed  Google Scholar 

  5. Mullen KD. Mechanisms, diagnosis and management of hepatic encephalopathy. Nat Rev Gastroenterol Hepatol. 2010;7:515–25.

    Article  PubMed  Google Scholar 

  6. Leise MD, Poterucha JJ, Kamath PS, Kim WR. Management of hepatic encephalopathy in the hospital. Mayo Clin Proc. 2014;89:241–53.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Nardone R, Höller Y, Storti M, et al. Spinal cord involvement in patients with cirrhosis. World J Gastroenterol. 2014;20:2578–85. A clinically oriented review of this rare complication of chronic hepatic failure.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Renjen PN, Khanna L, Rastogi R, Khan NI. Acquired hepatocerebral degeneration. BMJ Case Rep. 2013. doi:10.1136/bcr-2013-009387.

  9. Ferrara J, Jankovic J. Acquired hepatocerebral degeneration. J Neurol. 2009;256:320–32.

    Article  PubMed  Google Scholar 

  10. Fernández-Rodriguez R, Contreras A, De Villoria JG, Grandas F. Acquired hepatocerebral degeneration: clinical characteristics and MRI findings. Eur J Neurol. 2010;17:1463–70.

    Article  PubMed  Google Scholar 

  11. Maffeo E, Montuschi A, Stura G, Giordana MT. Chronic acquired hepatocerebral degeneration, pallidal T1 MRI hyperintensity and manganese in a series of cirrhotic patients. Neurol Sci. 2014;35:523–30.

    Article  PubMed  Google Scholar 

  12. Junker AE, Als-Nielsen B, Gluud C, Gluud LL. Dopamine agents for hepatic encephalopathy. Cochrane Database Syst Rev. 2014;2, CD003047.

    PubMed  Google Scholar 

  13. Stracciari A, Baldin E, Cretella L, et al. Chronic acquired hepatocerebral degeneration: effects of liver transplantation on neurological manifestations. Neurol Sci. 2011;32:411–5. A case series of 3 patients with acquired hepatocerebral degeneration who received hepatic transplant showing improvement in 2 of them.

    Article  PubMed  CAS  Google Scholar 

  14. El Moutawakil B, Bourezgui M, Rafai MA, et al. Acute disseminated encephalomyelitis associated with hepatitis A virus infection. Rev Neurol (Paris). 2008;164:852–4.

    Article  Google Scholar 

  15. Yimam KK, Merriman RB, Todd FR. A rare case of acute hepatitis B virus infection causing Guillain-Barre syndrome. Gastroenterol Hepatol (NY). 2013;9:121–3.

    Google Scholar 

  16. Mehndiratta M, Pandey S, Nayak R, Saran RK. Acute onset distal symmetrical vasculitic polyneuropathy associated with acute hepatitis B. J Clin Neurosci. 2013;20:331–2.

    Article  PubMed  Google Scholar 

  17. Monaco S, Ferrari S, Gajofatto A, et al. HCV-related nervous system disorders. Clin Dev Immunol. 2012;2012:236148. An extensive review of the mechanisms and clinical aspects of HCV neurologic complications.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Adinolfi LE, Zampino R, Restivo L, et al. Chronic hepatitis C virus infection and atherosclerosis: clinical impact and mechanisms. World J Gastroenterol. 2014;20:3410–7.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Huang H, Kang R, Xhao Z. Hepatitis C vírus infection and risk of stroke: a systematic review and meta-analysis. PloS One. 2013;8(11):e81305.

    Article  CAS  Google Scholar 

  20. Ahmad D, Ilias Basha H, Towfiq B, Bachuwa G. Resolution of neurological deficits secondary to spontaneous intracranial haemorrhage and posterior reversible encephalopathy syndrome (PRES) in a patient with hepatitis C-associated cryoglobulinaemia: a role for plasmapheresis. BMJ Case Rep. 2014;2014.

  21. Cheung MC, Maguire J, Carey I, et al. Review of the neurological manifestations of hepatitis E infection. Ann Hepatol. 2012;11:618–22. A literature review of 25 cases of patients with hepatitis E and neurologic manifestations.

    PubMed  Google Scholar 

  22. Hornik A, Rodriguez Porcel FJ, Agha C, et al. Central and extrapontine myelinolysis affecting the brain and spinal cord. An unusual presentation of pancreatic encephalopathy. Front Neurol. 2012;3:135. Case report of a woman with pancreatitis, encephalopathy and pontine and extrapontine myelinolysis.

    PubMed  PubMed Central  Google Scholar 

  23. Estrada RV, Moreno J, Martinez E, et al. Pancreatic encephalopathy. Acta Neurol Scand. 1979;59:135–9.

    Article  PubMed  CAS  Google Scholar 

  24. Arana-Guajardo AC, Cámara-Lemarroy CR, Rendón-Ramírez EJ, et al. Wernicke encephalopathy presenting in a patient with severe acute pancreatitis. JOP. 2012;13:104–7.

    PubMed  Google Scholar 

  25. Ahrens CL, Manno EM. Neurotoxicity of commonly used hepatic drugs. Handb Clin Neurol. 2014;120:675–82.

    Article  PubMed  Google Scholar 

  26. Ferro JM, Oliveira SN, Correia L. Neurologic manifestations of inflammatory bowel diseases. Handb Clin Neurol. 2014;120:595–605.

    Article  PubMed  Google Scholar 

  27. Oliveira GR, Teles BC, Brasil EF, et al. Peripheral neuropathy and neurological disorders in an unselected Brazilian population-based cohort of IBD patients. Inflamm Bowel Dis. 2008;14:389–95.

    Article  PubMed  CAS  Google Scholar 

  28. Gondim FA, Brannagan TH, Sander HW, et al. Peripheral neuropathy in patients with inflammatory bowel disease. Brain. 2005;128:867–79.

    Article  PubMed  CAS  Google Scholar 

  29. Canero A, Parmeggiani D, Avenia N, et al. Thromboembolic tendency (TE) in IBD (Inflammatory bowel disease) patients. Ann Ital Chir. 2012;83:313–7.

    PubMed  Google Scholar 

  30. Kappelman MD, Horvath-Puho E, Sandler RS, et al. Thromboembolic risk among Danish children and adults with inflammatory bowel diseases: a population-based nationwide study. Gut. 2011;60:937–43.

    Article  PubMed  Google Scholar 

  31. Barclay AR, Keightley JM, Horrocks I, et al. Cerebral thromboembolic events in pediatric patients with inflammatory bowel disease. Inflamm Bowel Dis. 2010;16:677–83.

    Article  PubMed  CAS  Google Scholar 

  32. Benavente L, Morís G. Neurologic disorders associated with inflammatory bowel disease. Eur J Neurol. 2011;18:138–43.

    Article  PubMed  CAS  Google Scholar 

  33. Cognat E, Crassard I, Denier C, et al. Cerebral venous thrombosis in inflammatory bowel diseases: eight cases and literature review. Int J Stroke. 2011;6:487–92. A case series of 8 patients cerebral venous thrombosis associated with inflammatory bowel diseases followed by a literature review.

    Article  PubMed  Google Scholar 

  34. Bermejo PE, Burgos A. Neurological complications of inflammatory bowel disease. Med Clin (Barc). 2008;130:666–75.

    Article  Google Scholar 

  35. Kreuzpaintner G, Horstkotte D, Heyll A, et al. Increased risk of bacterial endocarditis in inflammatory bowel disease. Am J Med. 1992;92:391–5.

    Article  PubMed  CAS  Google Scholar 

  36. Chentanez T, Khawcharoenporn T, Chokrungvaranon N, et al. Cardiobacterium hominis endocarditis presenting as acute embolic stroke: a case report and review of the literature. Heart Lung. 2011;40:262–9.

    Article  PubMed  Google Scholar 

  37. Gobron C, Kaci R, Sokol H, et al. Unilateral carotid granulomatous arteritis and Crohn's disease. Rev Neurol (Paris). 2010;166:542–6.

    Article  CAS  Google Scholar 

  38. Nudelman RJ, Rosen DG, Rouah E, Verstovsek G. Cerebral sinus thrombosis: a fatal neurological complication of ulcerative colitis. Pathol Res Int. 2010;2010:132754.

    Article  Google Scholar 

  39. Casella G, Spreafico C, Costantini M, et al. Cerebral sinus thrombosis in ulcerative colitis. Inflamm Bowel Dis. 2011;17:2214–6.

    Article  PubMed  Google Scholar 

  40. Katsanos AH, Katsanos KH, Kosmidou M, et al. Cerebral sinus venous thrombosis in inflammatory bowel diseases. QJM. 2012;106:401–13.

    Article  PubMed  Google Scholar 

  41. Tsujikawa T, Urabe M, Bamba H, et al. Haemorrhagic cerebral sinus thrombosis associated with ulcerative colitis: a case report of successful treatment by anticoagulant therapy. J Gastroenterol Hepatol. 2000;15:688–92.

    Article  PubMed  CAS  Google Scholar 

  42. Philips MF, Bagley LJ, Sinson GP, et al. Endovascular thrombolysis for symptomatic cerebral venous thrombosis. J Neurosurg. 1999;90:65–71.

    Article  PubMed  CAS  Google Scholar 

  43. Kothur K, Kaul S, Rammurthi S, et al. Use of thrombolytic therapy in cerebral venous sinus thrombosis with ulcerative colitis. Ann Indian Acad Neurol. 2012;15:35–8.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Rang EH, Brooke BN, Hermon-Taylor J. Association of ulcerative colitis with multiple sclerosis. Lancet. 1982;2:555.

    Article  PubMed  CAS  Google Scholar 

  45. Pandian JD, Pawar G, Singh GS, et al. Multiple sclerosis in a patient with chronic ulcerative colitis. Neurol India. 2004;52:282–3.

    PubMed  CAS  Google Scholar 

  46. Bernstein CN, Wajda A, Blanchard JF. The clustering of other chronic inflammatory diseases in inflammatory bowel disease: a population-based study. Gastroenterology. 2005;129:827–36.

    Article  PubMed  Google Scholar 

  47. Gupta G, Gelfand JM, Lewis JD. Increased risk for demyelinating diseases in patients with inflammatory bowel disease. Gastroenterology. 2005;129:819–26.

    Article  PubMed  Google Scholar 

  48. Thomas Jr CW, Weinshenker BG, Sandborn WJ. Demyelination during anti-tumor necrosis factor therapy with infliximab for Crohn’s disease. Inflamm Bowel Dis. 2004;10:28–31.

    Article  PubMed  Google Scholar 

  49. Freeman HJ, Flak B. Demyelination-like syndrome in Crohn’s disease after infliximab therapy. Can J Gastroenterol. 2005;19:313–6.

    PubMed  Google Scholar 

  50. Sacher M, Göpfrich H, Hochberger O. Crohn's disease penetrating into the spinal canal. Acta Paediatr Scand. 1989;78:647–9.

    Article  PubMed  CAS  Google Scholar 

  51. Hershkowitz S, Link R, Ravden M, Lipow K. Spinal empyema in Crohn's disease. J Clin Gastroenterol. 1990;12:67–9.

    Article  PubMed  CAS  Google Scholar 

  52. Heidemann J, Spinelli KS, Otterson MF, Binion DG. Case report: magnetic resonance imaging in the diagnosis of epidural abscess complicating perirectal fistulizing Crohn's disease. Inflamm Bowel Dis. 2003;9:122–4.

    Article  PubMed  Google Scholar 

  53. Laplante P, Vanase M, Michaud J, et al. A progressive neurological syndrome associated with an isolated vitamin E deficiency. Can J Neurol Sci. 1984;11(4 Suppl):561–4.

    PubMed  CAS  Google Scholar 

  54. Ayuso Blanco T, Martin Martinez J, Figueras P, et al. Chronic polyneuropathy due to vitamin E deficiency. Neurologia. 1994;9:300–2.

    PubMed  CAS  Google Scholar 

  55. Rino Y, Suzuki Y, Kuroiwa Y, et al. Vitamin E malabsorption and neurological consequences after gastrectomy for gastric cancer. Hepato–Gastroenterol. 2007;54:1858–61.

    Google Scholar 

  56. Ueda N, Suzuki Y, Rino Y, et al. Correlation between neurological dysfunction with vitamin E deficiency and gastrectomy. J Neurol Sci. 2009;287:216–20.

    Article  PubMed  CAS  Google Scholar 

  57. Sokol RJ, Kim YS, Hoofnagle JH, et al. Intestinal malabsorption of vitamin E in primary biliary cirrhosis. Gastroenterology. 1989;96:479–86.

    PubMed  CAS  Google Scholar 

  58. Yokota T, Tsuchiya K, Furukawa T, et al. Vitamin E deficiency in acquired fat malabsorption. J Neurol. 1990;237:103–6.

    Article  PubMed  CAS  Google Scholar 

  59. Aslam A, Misbah SA, Talbot K, et al. Vitamin E deficiency induced neurological disease in common variable immunodeficiency: two cases and review of literature of vitamin E deficiency. Clin Immunol. 2004;112:24–9.

    Article  PubMed  CAS  Google Scholar 

  60. Howard L, Ovesen L, Satya-Murti S, et al. Reversible neurological symptoms caused by vitamin E deficiency in a patient with short bowel syndrome. Am J Clin Nutr. 1982;36:1243–9.

    PubMed  CAS  Google Scholar 

  61. Vorgerd M, Tegenthoff M, Kühne D, et al. Spinal MRI in progressive myeloneuropathy associated with vitamin E deficiency. Neuroradiology. 1996;38 Suppl 1:S111–3.

    Article  PubMed  Google Scholar 

  62. Bye AM, Muller DP, Wilson J, et al. Symptomatic vitamin E deficiency in cystic fibrosis. Arch Dis Child. 1985;60:162–4.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  63. Wernicke C. Lehrbuch der Gehirnkrankheiten fur Aerzte und Studirende. Kassel: Theodor Fisher; 1881.

    Google Scholar 

  64. Rothrock JF, Smith MS. Wernicke’s disease complicating surgical therapy for morbid obesity. J Clin Neuroophthalmol. 1981;1:195–9.

    PubMed  CAS  Google Scholar 

  65. Aasheim ET, Bjorkman S, Sevik TT, et al. Vitamin status after bariatric surgery: a randomized study of gastric bypass and duodenal switch. Am J Clin Nutr. 2009;90:15–22.

    Article  PubMed  Google Scholar 

  66. Aasheim ET. Wernicke encephalopathy after bariatric surgery: a systematic review. Ann Surg. 2008;248:714–20.

    PubMed  Google Scholar 

  67. Kramer LD, Locke GE. Wernicke’s encephalopathy. Complication of gastric plication. J Clin Gastroenterol. 1987;9:549–52.

    Article  PubMed  CAS  Google Scholar 

  68. Koike H, Misu K, Hattori N, et al. Postgastrectomy polyneuropathy with thiamine deficiency. J Neurol Neurosurg Psychiatry. 2001;71:357–62.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  69. Berger JR, Singhal D. The neurologic complications of bariatric surgery. Handb Clin Neurol. 2014;120:587–94.

    Article  PubMed  Google Scholar 

  70. Anderes E, Nand S. Commonly used drugs in hematologic disorders. Handb Clin Neurol. 2014;120:1125–39.

    Article  PubMed  Google Scholar 

  71. Kumar N. Copper deficiency myelopathy (human swayback). Mayo Clin Proc. 2006;81:1371–84.

    Article  PubMed  CAS  Google Scholar 

  72. Kumar N, Gross Jr JB, Ahlskog JE. Copper deficiency myelopathy produces a clinical picture like subacute degeneration. Neurology. 2004;63:33–9.

    Article  PubMed  CAS  Google Scholar 

  73. Kumar N, Ahlskog JE, Klein CJ, et al. Imaging features of copper deficiency myelopathy: a study of 25 cases. Neuroradiology. 2006;48:78–83.

    Article  PubMed  Google Scholar 

  74. Abarbanel JM, Berginer VM, Osimani A, et al. Neurologic complications after gastric restriction surgery for morbid obesity. Neurology. 1987;37:196–200.

    Article  PubMed  CAS  Google Scholar 

  75. Peters G, du Plessis DG, Humphrey PR. Cerebral Whipple’s disease with a stroke-like presentation and cerebrovascular pathology. J Neurol Neurosurg Psychiatry. 2002;73:336–9.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  76. Lagier J-C, Fenollar F, Lepidi H, et al. Failure and relapse after treatment with trimethoprim/sulfamethoxazole in classic Whipple’s disease. J Antimicrob Chemother. 2010;65:2005–12.

    Article  PubMed  CAS  Google Scholar 

  77. Cirignotta F, Manconi M, Mondini S, et al. Wernicke-Korsakoff encephalopathy and polyneuropathy after gastroplasty for morbid obesity: report of a case. Arch Neurol. 2000;57:1356–9.

    Article  PubMed  CAS  Google Scholar 

  78. Compain C, Sacre K, Puéchal X, et al. Central nervous system involvement in Whipple disease: clinical study of 18 patients and long-term follow-up. Medicine. 2013;92:324–30.

    Article  PubMed  Google Scholar 

  79. Mohamed W, Neil E, Kupsky WJ, et al. Isolated intracranial Whipple's disease—report of a rare case and review of the literature. J Neurol Sci. 2011;308:1–8. A case report and systematic review of 24 cases of isolated intracranial presentation of Whipple’s disease. Most cases had a rapidly progressive atypical dementia.

    Article  PubMed  Google Scholar 

  80. Blanc F, Ben Abdelghani K, Schramm F, et al. Whipple limbic encephalitis. Arch Neurol. 2011;68:1471–3.

    Article  PubMed  Google Scholar 

  81. Black DF, Aksamit AJ, Morris JM. MR imaging of central nervous system Whipple disease: a 15-year review. AJNR. 2010;31:1493–7.

    Article  PubMed  CAS  Google Scholar 

  82. Hadjivassiliou M, Duker AP, Sanders DS. Gluten-related neurologic dysfunction. Handb Clin Neurol. 2014;120:607–19.

    Article  PubMed  Google Scholar 

  83. Briani C, Zara G, Alaedini A, et al. Neurological complications of coeliac disease and autoimmune mechanisms: a prospective study. J Neuroimmunol. 2008;195:171–5.

    Article  PubMed  CAS  Google Scholar 

  84. Hadjivassiliou M, Maki M, Sanders DS, et al. Autoantibody targeting of Brain. and intestinal transglutaminase in gluten ataxia. Neurology. 2006;66:373–7.

    Article  PubMed  CAS  Google Scholar 

  85. Hadjivassiliou M, Aeschlimann P, Strigun A, et al. Autoantibodies in gluten ataxia recognise a novel neuronal transglutaminase. Ann Neurol. 2008;64:332–43.

    Article  PubMed  CAS  Google Scholar 

  86. Hadjivassiliou M, Grunewald RA, Chattopadhyay AK, et al. Clinical, radiological, neurophysiological and neuropathological characteristics of gluten ataxia. Lancet. 1998;352:1582–5.

    Article  PubMed  CAS  Google Scholar 

  87. Hadjivassiliou M, Sanders DS, Woodroofe N, et al. Gluten ataxia. Cerebellum. 2008;7:494–8.

    Article  PubMed  CAS  Google Scholar 

  88. Deconinck N, Scaillon M, Segers V, et al. Opsoclonus-myoclonus associated with celiac disease. Pediatr Neurol. 2006;34:312–4.

    Article  PubMed  Google Scholar 

  89. Hadjivassiliou M, Davies-Jones GAB, Sanders DS, et al. Dietary treatment of gluten ataxia. J Neurol Neurosurg Psychiatry. 2003;74:1221–4.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  90. Currie S, Hadjivassiliou M, Clark MJ, et al. Should we be ‘nervous’ about coeliac disease? Brain. abnormalities in patients with coeliac disease referred for neurological opinion. J Neurol Neurosurg Psychiatry. 2012;83:1216–21. A detailed quantified MR study indicating that patients with gluten sensitivity have decreased cerebellar volume and other MR abnormalities.

    Article  PubMed  Google Scholar 

  91. Hadjivassiliou M, Grünewald RAG, Lawden M, et al. Headache and CNS white matter abnormalities associated with gluten sensitivity. Neurology. 2001;56:5–388.

    Google Scholar 

  92. Hu WT, Murray JA, Greenway MC, et al. Cognitive impairment and celiac disease. Arch Neurol. 2006;63:1440–6.

    Article  PubMed  Google Scholar 

  93. Ludvigsson JF, Zingone F, Tomson T, et al. Increased risk of epilepsy in biopsy-verified celiac disease: a population-based cohort study. Neurology. 2012;78:1401–7.

    Article  PubMed  CAS  Google Scholar 

  94. Gobbi G. Coeliac disease, epilepsy and cerebral calcifications. Brain Dev. 2005;27:189–200.

    Article  PubMed  Google Scholar 

  95. Luostarinen L, Himanen SL, Luostarinen M, et al. Neuromuscular and sensory disturbances in patients with well treated celiac disease. J Neurol Neurosurg Psychiatry. 2003;74:490–4.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  96. Hadjivassiliou M, Grunewald RA, Kandler RH, et al. Neuropathy associated with gluten sensitivity. J Neurol Neurosurg Psychiatry. 2006;77:1262–6.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  97. Hadjivassiliou M, Rao DS, Wharton SB, et al. Sensory ganglionopathy due to gluten sensitivity. Neurology. 2010;75:1003–8.

    Article  PubMed  CAS  Google Scholar 

  98. Henriksson KG, Hallert C, Norrby K, et al. Polymyositis and adult celiac disease. Acta Neurol Scand. 1982;65:301–19.

    Article  PubMed  CAS  Google Scholar 

  99. Hadjivassiliou M, Chattopadhyay AK, Grunewald RA, et al. Myopathy associated with gluten sensitivity. Muscle Nerve. 2007;35:443–50.

    Article  PubMed  CAS  Google Scholar 

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José M. Ferro and Sofia Oliveira declare that they have no conflict of interest.

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Ferro, J.M., Oliveira, S. Neurologic Manifestations of Gastrointestinal and Liver Diseases. Curr Neurol Neurosci Rep 14, 487 (2014). https://doi.org/10.1007/s11910-014-0487-z

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