Inflammation and Immune System Activation After Traumatic Brain Injury
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- Balu, R. Curr Neurol Neurosci Rep (2014) 14: 484. doi:10.1007/s11910-014-0484-2
Treatment options for managing traumatic brain injury remain limited. Therapies that limit the development of secondary brain injury—the delayed injury that can occur days to weeks after initial presentation—would have a major impact on outcomes and reduce the medical, social, and economic burden of this devastating disease. A growing body of evidence suggests that inflammation and activation of the immune system is a central driver of secondary brain injury. This article reviews the evidence for inflammation mediating secondary injury after head trauma and outlines potential approaches for immunomodulatory therapies after traumatic brain injury.