Date: 20 Aug 2014

Inflammation and Immune System Activation After Traumatic Brain Injury

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Abstract

Treatment options for managing traumatic brain injury remain limited. Therapies that limit the development of secondary brain injury—the delayed injury that can occur days to weeks after initial presentation—would have a major impact on outcomes and reduce the medical, social, and economic burden of this devastating disease. A growing body of evidence suggests that inflammation and activation of the immune system is a central driver of secondary brain injury. This article reviews the evidence for inflammation mediating secondary injury after head trauma and outlines potential approaches for immunomodulatory therapies after traumatic brain injury.

This article is part of the Topical Collection on Neurotrauma