Current Neurology and Neuroscience Reports

, 14:457

Neurologic Complications of Diabetes

  • Gerald A. Charnogursky
  • Nicholas V. Emanuele
  • Mary Ann Emanuele
Neurology of Systemic Disease (J Biller, Section Editor)

DOI: 10.1007/s11910-014-0457-5

Cite this article as:
Charnogursky, G.A., Emanuele, N.V. & Emanuele, M.A. Curr Neurol Neurosci Rep (2014) 14: 457. doi:10.1007/s11910-014-0457-5
Part of the following topical collections:
  1. Topical Collection on Neurology of Systemic Disease


Neuropathy as a complication of diabetes is common and presents in a wide variety of clinical scenarios. Often the work-up is one of exclusion tempered with monitoring the response of symptoms to treatment options. The collaboration of a neurologist is often crucial to determining the best course of action for the patient. This review will address proposed pathogenic mechanisms and potential therapeutic interventions, both pharmacologic and nonpharmacologic.


PathogenesisDiabetic neuropathyPainful peripheral neuropathyDiabetic autonomic neuropathyDiabetic cardiovascular neuropathyDiabetic gastroparesisTherapeutic treatment diabetic neuropathy



Insulin-like growth factors


Nicotinamide adenine dinucleotide phosphate hydrogen


Neuropathy Impairment Score


Receptor for Advanced Glycation end products


Transient receptor potential channel

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Gerald A. Charnogursky
    • 1
  • Nicholas V. Emanuele
    • 1
  • Mary Ann Emanuele
    • 1
  1. 1.Division of Endocrinology and MetabolismLoyola University Medical CenterMaywoodUSA