Neurology of Rheumatologic Disorders

Neurology of Systemic Disease (J Biller, Section Editor)

DOI: 10.1007/s11910-014-0456-6

Cite this article as:
Nouh, A., Carbunar, O. & Ruland, S. Curr Neurol Neurosci Rep (2014) 14: 456. doi:10.1007/s11910-014-0456-6
Part of the following topical collections:
  1. Topical Collection on Neurology of Systemic Disease


Rheumatologic diseases encompass autoimmune and inflammatory disorders of the joints and soft tissues that often involve multiple organ systems, including the central and peripheral nervous systems. Common features include constitutional symptoms, arthralgia and arthritis, myalgia, and sicca symptoms. Neurological manifestations may present in patients with preexisting rheumatologic diagnoses, occur concurrently with systemic signs and symptoms, or precede systemic manifestations by months to years. Rheumatic disorders presenting as neurological syndromes may pose diagnostic challenges. Advances in immunosuppressive treatment of rheumatologic disease have expanded the treatment armamentarium. However, serious neurotoxic effects have been reported with both old and newer agents. Familiarity with neurological manifestations of rheumatologic diseases, diagnosis, and potential nervous system consequences of treatment is important for rapid diagnosis and appropriate intervention. This article briefly reviews the diverse neurological manifestations and key clinical features of rheumatic disorders and the potential neurological complications of agents commonly used for treatment.


Connective tissue disease Systemic lupus erythematosus Neuropsychiatric lupus Antiphospholipid antibody syndrome Rheumatoid arthritis Sjögren’s syndrome Vasculitis Giant cell arteritis Takayasu’s arteritis Immune complex vasculitis Antineutrophil-cytoplasmic-antibody-associated vasculitis Behçet’s disease Stroke Mononeuritis multiplex Neuropathy Cranial neuropathy Myelopathy Inflammatory myositis Dermatomyositis Polymyositis Inclusion body myositis Sarcoidosis Neurosarcoidosis IgG4-related disorders Neurotoxicity 

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of Neurology, Maguire 2700 Building 105Loyola University Medical Center, Stritch School of MedicineMaywoodUSA
  2. 2.Department of NeurologyCleveland Clinic of FloridaWestonUSA

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