Resting State Functional Magnetic Resonance Imaging in Parkinson’s Disease

  • Janey Prodoehl
  • Roxana G. Burciu
  • David E. Vaillancourt
Movement Disorders (M Okun, Section Editor)

DOI: 10.1007/s11910-014-0448-6

Cite this article as:
Prodoehl, J., Burciu, R.G. & Vaillancourt, D.E. Curr Neurol Neurosci Rep (2014) 14: 448. doi:10.1007/s11910-014-0448-6
Part of the following topical collections:
  1. Topical Collection on Movement Disorders


Neuroimaging advances over the past several decades have provided increased understanding of the structural and functional brain changes that occur with Parkinson’s disease (PD). Examination of resting state functional magnetic resonance imaging (rs-fMRI) provides a noninvasive method that focuses on low-frequency spontaneous fluctuations in the blood-oxygenation-level-dependent signal that occurs when an individual is at rest. Several analysis methods have been developed and used to explore how PD affects resting state activity and functional connectivity, and the purpose of this review is to highlight the critical advances made thus far. Some discrepancies in the rs-fMRI and PD literature exist, and we make recommendations for consideration in future studies. The rs-fMRI technique holds promise for investigating brain changes associated with the motor and nonmotor symptoms of PD, and for revealing important variations across large-scale networks of the brain in PD.


fMRI Resting Connectivity Network Parkinson’s disease 

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Janey Prodoehl
    • 1
  • Roxana G. Burciu
    • 2
  • David E. Vaillancourt
    • 2
    • 3
    • 4
  1. 1.Physical Therapy ProgramMidwestern UniversityDowners GroveUSA
  2. 2.Department of Applied Physiology and KinesiologyUniversity of FloridaGainesvilleUSA
  3. 3.Department of Neurology and Center for Movement Disorders and NeurorestorationUniversity of FloridaGainesvilleUSA
  4. 4.Department of Biomedical EngineeringUniversity of FloridaGainesvilleUSA