Opportunistic Infections of the Central Nervous System in the Transplant Patient

Infection (J Berger)

DOI: 10.1007/s11910-013-0376-x

Cite this article as:
Cohen, B.A. & Stosor, V. Curr Neurol Neurosci Rep (2013) 13: 376. doi:10.1007/s11910-013-0376-x
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  1. Topical Collection on Infection

Abstract

Therapeutic advances in transplantation medicine have resulted in ever expanding patient populations that receive organ or stem cell transplantation. Modern potent immunomodulatory therapies have resulted in improvements in allograft and patient survival, but, consequently, as a result of the immunosuppressive state, transplant recipients are highly vulnerable to infection, including those that affect the central nervous system (CNS). CNS infections present a diagnostic and therapeutic challenge for clinicians involved in the care of the transplant patient, with a propensity to result in profound morbidity and often high mortality in this patient population. Here, we review major opportunistic pathogens of the CNS seen in transplant patients, highlighting distinguishing epidemiologic and clinical features.

Keywords

Nervous system infection Opportunistic infection Organ transplantation Stem cell transplantation Meningoencephalitis Meningitis Encephalitis Cerebritis Brain abscess Myelitis Progressive multifocal leukoencephalopathy Cytomegalovirus Epstein–Barr virus Herpes simplex virus Human herpesvirus-6 Human herpesvirus-7 Varicella-zoster virus JC virus Toxoplasma gondii Aspergillus Cryptococcus Mucormycosis Listeria monocytogenes Nocardia Mycobacterium tuberculosis 

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Davee Department of Neurology and Clinical NeurosciencesNorthwestern University Feinberg School of MedicineChicagoUSA
  2. 2.Department of MedicineNorthwestern University Feinberg School of MedicineChicagoUSA
  3. 3.Department of SurgeryNorthwestern University Feinberg School of MedicineChicagoUSA
  4. 4.Comprehensive Transplant Center,Northwestern University Feinberg School of MedicineChicagoUSA

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