Current Neurology and Neuroscience Reports

, Volume 12, Issue 5, pp 492–501

Clinical Trials of Dementia With Lewy Bodies and Parkinson’s Disease Dementia

  • D. Aarsland
  • C. Ballard
  • A. Rongve
  • M. Broadstock
  • P. Svenningsson
Dementia (KS Marder, Section Editor)

DOI: 10.1007/s11910-012-0290-7

Cite this article as:
Aarsland, D., Ballard, C., Rongve, A. et al. Curr Neurol Neurosci Rep (2012) 12: 492. doi:10.1007/s11910-012-0290-7

Abstract

Despite the frequency and importance of dementia associated with Parkinson’s disease (PDD) and dementia with Lewy bodies (DLB), there is relatively little evidence on which to base treatment. Evidence from meta-analysis suggests that rivastigmine can improve cognition and functioning in PDD and also reduce risk of falling. There is also evidence supporting its use in DLB. Recent evidence suggests that memantine may also be effective, particularly for PDD, although evidence is more conflicting. Memantine may also improve parkinsonism and dyskinesias. Few clinical trials of cognition in PD without dementia exist, but there is preliminary evidence for atomoxetine, memantine, and piribedil. There is a lack of systematic evidence for the treatment of visual hallucinations and depression in PDD and DLB. In addition, there is a need for studies of whether potentially disease-modifying agents can prevent or delay the progression to dementia in PD.

Keywords

Parkinson’s diseaseDementiaDementia with Lewy bodiesRivastigmineMemantineCholinesterase inhibitors

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • D. Aarsland
    • 1
    • 2
    • 3
  • C. Ballard
    • 5
  • A. Rongve
    • 4
  • M. Broadstock
    • 6
  • P. Svenningsson
    • 7
  1. 1.Alzheimer’s Disease Research Centre, NovumKarolinska InstitutetStockholmSweden
  2. 2.Centre for Age-Related DiseasesStavanger University HospitalStavangerNorway
  3. 3.Faculty of MedicineUniversity of OsloOsloNorway
  4. 4.Department of Old Age Psychiatry and ResearchHaugesund Hospital, Psychiatric ClinicHaugesundNorway
  5. 5.Age Related DiseasesKing’s College London, Wolfson Centre for Age Related DiseasesLondonUK
  6. 6.Edmond and Lily Safra Research FellowKing’s College London, Wolfson Centre for Age-Related DiseasesLondonUK
  7. 7.Department of Neurology and Clinical Neuroscience, Center for Molecular MedicineKarolinska Institutet and Karolinska University HospitalStockholmSweden