, Volume 11, Issue 6, pp 520-522
Date: 10 Sep 2011

Efficacy and Safety of Antidepressant Drugs in Patients with Dementia

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Trial: Banerjee S, Hellier J, Dewey M, et al.: Sertraline or mirtazapine for depression in dementia (HTA-SADD): a randomized, multicentre, double-blind, placebo-controlled trial. Lancet 2011, 378:403–411.

Rating: •Of major importance.

Keywords Depression.Dementia.Antidepressant drugs.Selective serotonin reuptake inhibitors (SSRIs).Sertraline.Mirtazapine.Cognitive impairment.Cornell Scale for Depression in Dementia (CSDD)

Introduction: Management of the behavioral disorders associated with Alzheimer’s disease (AD) has been in considerable flux. Most patients with AD eventually develop behavioral symptoms such as depression, anxiety, and later, agitation, hallucinations, and delusional thinking. These symptoms are very distressing to families and often play a greater role in the inability of families to care for patients at home than do the cognitive deficits. Treatment with antipsychotic drugs, in particular, has been controversial, because of the risks of mortality, stroke, myocardial inf