Current Neurology and Neuroscience Reports

, Volume 11, Issue 3, pp 246–253

Alzheimer’s Genetics in the GWAS Era: A Continuing Story of ‘Replications and Refutations’

Article

DOI: 10.1007/s11910-011-0193-z

Cite this article as:
Bertram, L. Curr Neurol Neurosci Rep (2011) 11: 246. doi:10.1007/s11910-011-0193-z

Abstract

After a decade of intensive investigation but only few replicable results, Alzheimer’s disease (AD) genetics research is slowly picking up pace. This is mostly owing to the completion of several genome-wide association studies (GWAS), which have suggested the existence of over three dozen potential new AD susceptibility genes. Although only a handful of these could be confirmed in subsequent independent replication efforts to date, this success rate is still much higher than in the pre-GWAS era. This review provides a brief summary of the principal methodologic advances in genetics research of the past decade, followed by a description of the most compelling findings that these advances have unearthed in AD. The paper closes with a discussion of the persistent methodologic difficulties and challenges and an outlook on what we can expect to gain from the next 10 years of AD genetics research.

Keywords

Alzheimer’s diseaseCausal genesRisk genesSusceptibility factorsGenome-wide association studyMeta-analysisComplex genetics

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department Vertebrate Genomics, Neuropsychiatric Genetics GroupMax-Planck Institute for Molecular GeneticsBerlinGermany