Current Neurology and Neuroscience Reports

, Volume 11, Issue 3, pp 254–261

Genetics of Neurodegeneration with Brain Iron Accumulation

Authors

    • Department of Molecular & Medical GeneticsOregon Health & Science University
  • Susan J. Hayflick
    • Departments of Molecular & Medical GeneticsPediatrics & Neurology
Article

DOI: 10.1007/s11910-011-0181-3

Cite this article as:
Gregory, A. & Hayflick, S.J. Curr Neurol Neurosci Rep (2011) 11: 254. doi:10.1007/s11910-011-0181-3

Abstract

The condition originally called Hallervorden-Spatz syndrome is a collection of related disorders involving abnormal iron accumulation in the basal ganglia, usually manifesting with a movement disorder. To date, mutations in the following genes have been associated with neurodegeneration with brain iron accumulation (NBIA) phenotypes: PANK2, PLA2G6, FA2H, ATP13A2, C2orf37, CP, and FTL. This collection, now classified under the umbrella term NBIA, continues to evolve as new genes and associated phenotypes are recognized. As this body of information continues to grow, better approaches to diagnosis and treatment have become available. Continued investigations of the underlying pathogenesis of disease, with a focus on lipid, iron, and energy metabolism, will lead to the identification of new therapeutic targets.

Keywords

Neurodegeneration with brain iron accumulationNBIAPantothenate kinase-associated neurodegenerationPKANNeuroaxonal dystrophyINADDystonia-parkinsonismPLANFatty acid hydroxylase-associated neurodegenerationWoodhouse-Sakati syndromeKufor-Rakeb syndromeAceruloplasminemiaNeuroferritinopathyPANK2PLA2G6FA2HATP13A2, C2orf37CP, FTL

Copyright information

© Springer Science+Business Media, LLC 2011