, Volume 11, Issue 2, pp 124-126
Date: 04 Dec 2010

Risk Stratification of Medulloblastoma: A Paradigm for Future Childhood Brain Tumor Management Strategies

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Northcott PA, Korshunov A, Witt H, et al.: Medulloblastoma comprises four distinct molecular variants. J Clin Oncol 2010 Oct 4 [Epub ahead of print].

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Of significant importance.

Introduction

Brain tumors remain one of the most challenging forms of malignancies to effectively treat. Embryonal tumors are the most common form of malignant childhood brain tumor and, of the embryonal tumors, the most common is medulloblastoma. Occurring predominantly in children, they may also arise in adults. Medulloblastoma, which by definition arises in the posterior fossa, has been the focus of many contemporary clinical research studies [1, 2]. It is often used as an example of a tumor that is both radiosensitive and chemosensitive and one for which sequential clinical studies have demonstrated an apparent improvement in overall survival. As more children and, for that matter, young adults with medulloblastoma survive, it has become apparent that survivors face a host of severe sequelae interfer