Current Neurology and Neuroscience Reports

, Volume 10, Issue 6, pp 484–490

The New Classification of Primary Progressive Aphasia into Semantic, Logopenic, or Nonfluent/Agrammatic Variants


DOI: 10.1007/s11910-010-0140-4

Cite this article as:
Bonner, M.F., Ash, S. & Grossman, M. Curr Neurol Neurosci Rep (2010) 10: 484. doi:10.1007/s11910-010-0140-4


Primary progressive aphasia (PPA), typically resulting from a neurodegenerative disease such as frontotemporal lobar degeneration or Alzheimer’s disease, is characterized by a progressive loss of specific language functions with relative sparing of other cognitive domains. Three variants of PPA are now recognized: semantic variant, logopenic variant, and nonfluent/agrammatic variant. We discuss recent work characterizing the neurolinguistic, neuropsychological, imaging and pathologic profiles associated with these variants. Improved reliability of diagnoses will be increasingly important as trials for etiology-specific treatments become available. We also discuss the implications of these syndromes for theories of language function.


Primary progressive aphasia (PPA)Semantic variant PPA (svPPA)Semantic dementia (SD)Semantic PPA (PPA-S)Logopenic variant PPA (lvPPA)Logopenic progressive aphasia (LPA)Logopenic PPA (PPA-L)Nonfluent/agrammatic variant PPA (navPPA)Progressive nonfluent aphasia (PNFA)Agrammatic PPA (PPA-G)Frontotemporal dementia (FTD, FTLD)Alzheimer’s disease (AD)

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Michael F. Bonner
    • 1
  • Sharon Ash
    • 1
    • 2
  • Murray Grossman
    • 1
  1. 1.Department of Neurology, 2 GibsonHospital of the University of PennsylvaniaPhiladelphiaUSA
  2. 2.Department of Neurology, 3 West GatesHospital of the University of PennsylvaniaPhiladelphiaUSA