Current Neurology and Neuroscience Reports

, Volume 10, Issue 5, pp 359–366

Hormonal Influences on Cognition and Risk for Alzheimer’s Disease


DOI: 10.1007/s11910-010-0122-6

Cite this article as:
Janicki, S.C. & Schupf, N. Curr Neurol Neurosci Rep (2010) 10: 359. doi:10.1007/s11910-010-0122-6


Research increasingly suggests that changes in estrogen levels during aging may increase the risk of Alzheimer’s disease, the most common type of dementia. This update reviews the newest information about estrogen and cognitive aging, including information regarding the role of bioavailable estrogen in older women and men, use of selective estrogen receptor modulators to improve cognition, and studies of genetic risk factors to elucidate the effects of endogenous estrogen on aging and cognition. Future trials are needed to determine whether alternate timing, dosage, formulation, or method of administration of hormone replacement can reduce the risk of dementia.


Alzheimer’s DiseaseDementiaEstrogenHormone Replacement TherapyGenetics

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.G. H. Sergievsky CenterColumbia University Medical CenterNew YorkUSA