Current Neurology and Neuroscience Reports

, Volume 10, Issue 2, pp 127-132

First online:

New Daily Persistent Headache in Children and Adolescents

  • Eric P. BaronAffiliated withDepartment of Neurology, Center for Headache and Pain/T33, Cleveland Clinic Neurological Institute Email author 
  • , A. David RothnerAffiliated withCenter for Pediatric Neurology/S60, Cleveland Clinic Neurological Institute

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New daily persistent headache (NDPH) is a form of chronic daily headache (CDH) that may have features of both migraine and tension-type headache. In contrast with other types of CDH, NDPH is characterized by patients recalling the specific date their unremitting daily headache began. In comparison, chronic tension-type headache and chronic migraine are preceded by a gradually increasing frequency of headache. After several months, all three of these CDH forms often have a similar phenotype, making early history a key to diagnosing NDPH. Evaluations to exclude secondary causes are necessary but usually negative. NDPH is difficult to treat and requires a multimodal approach. Questions regarding NDPH remain unanswered. Additional prospective studies are necessary to further understand, characterize, diagnose, and treat NDPH.


New daily persistent headache Chronic daily headache Children Adolescents Chronic migraine Chronic tension-type headache