Inclusion body myositis: Review of recent literature
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- Greenberg, S.A. Curr Neurol Neurosci Rep (2009) 9: 83. doi:10.1007/s11910-009-0013-x
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Inclusion body myositis (IBM) is a progressive inflammatory skeletal muscle disease of unknown cause and without effective treatment. This article discusses existing literature, emphasizing disease mechanisms and models. In particular, it addresses limitations in the β-amyloid-mediated theory of IBM myofiber injury, flawed rationales of animal models of this disease, and recent reports regarding treatment.