Current Neurology and Neuroscience Reports

, Volume 9, Issue 1, pp 83-89

First online:

Inclusion body myositis: Review of recent literature

  • Steven A. GreenbergAffiliated withDepartment of Neurology, Brigham and Women’s Hospital Email author 

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Inclusion body myositis (IBM) is a progressive inflammatory skeletal muscle disease of unknown cause and without effective treatment. This article discusses existing literature, emphasizing disease mechanisms and models. In particular, it addresses limitations in the β-amyloid-mediated theory of IBM myofiber injury, flawed rationales of animal models of this disease, and recent reports regarding treatment.