Current Neurology and Neuroscience Reports

, Volume 9, Issue 1, pp 83–89

Inclusion body myositis: Review of recent literature

Article

DOI: 10.1007/s11910-009-0013-x

Cite this article as:
Greenberg, S.A. Curr Neurol Neurosci Rep (2009) 9: 83. doi:10.1007/s11910-009-0013-x

Abstract

Inclusion body myositis (IBM) is a progressive inflammatory skeletal muscle disease of unknown cause and without effective treatment. This article discusses existing literature, emphasizing disease mechanisms and models. In particular, it addresses limitations in the β-amyloid-mediated theory of IBM myofiber injury, flawed rationales of animal models of this disease, and recent reports regarding treatment.

Copyright information

© Current Medicine Group LLC 2009

Authors and Affiliations

  1. 1.Department of NeurologyBrigham and Women’s HospitalBostonUSA