Recent advances in the genetics of dementia with Lewy bodies
- Vincenzo BonifatiAffiliated withDepartment of Clinical Genetics, Erasmus MC Email author
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In the past few years, mutations have been identified in the genes encoding α-synuclein, leucine-rich repeat kinase 2, and glucocerebrosidase in some patients with dementia with Lewy bodies (DLB). Furthermore, a novel locus for familial DLB has been mapped to chromosome 2q35-q36. Collectively, these discoveries highlight a substantial overlap between the known genetic determinants of Parkinson’s disease and DLB, as well as the presence of profound etiologic heterogeneity in Lewy body disorders.
- Recent advances in the genetics of dementia with Lewy bodies
Current Neurology and Neuroscience Reports
Volume 8, Issue 3 , pp 187-189
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- Current Science Inc.
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- 1. Department of Clinical Genetics, Erasmus MC, PO Box 2040, 3000 CA, Rotterdam, The Netherlands