Current Neurology and Neuroscience Reports

, Volume 7, Issue 6, pp 461–469

Progressive multifocal leukoencephalopathy


DOI: 10.1007/s11910-007-0072-9

Cite this article as:
Berger, J.R. Curr Neurol Neurosci Rep (2007) 7: 461. doi:10.1007/s11910-007-0072-9


Progressive multifocal leukoencephalopathy (PML) was a rare disease until the advent of the HIV/AIDS pandemic. Recent interest in the disorder has been spurred by its appearance in patients treated with the monoclonal antibodies natalizumab and rituximab. Unless the accompanying underlying immune deficit can be reversed, PML typically progresses to death fairly rapidly. Treatment directed against the JC virus has been unhelpful, but an increased understanding of disease pathogenesis may result in effective therapeutic strategies.

Copyright information

© Current Medicine Group LLC 2007

Authors and Affiliations

  1. 1.Department of NeurologyUniversity of Kentucky College of MedicineLexingtonUSA