Current Neurology and Neuroscience Reports

, Volume 5, Issue 3, pp 232–238

Nitric oxide and multiple sclerosis

  • Juan Manuel Encinas
  • Louis Manganas
  • Grigori Enikolopov

DOI: 10.1007/s11910-005-0051-y

Cite this article as:
Encinas, J.M., Manganas, L. & Enikolopov, G. Curr Neurol Neurosci Rep (2005) 5: 232. doi:10.1007/s11910-005-0051-y


Nitric oxide (NO) is a free radical signaling molecule with remarkably complex biochemistry. Its involvement in multiple sclerosis (MS) had been postulated soon after the discovery of the critical role NO plays in inflammation. However, the extent of NO’s contribution to MS is not yet understood, party due to the often opposing roles that NO can play in cellular processes. This review briefly covers new developments in the area of NO that may be relevant to MS. It also describes recent progress in understanding the role of NO in MS, new potential targets of the action of NO in the cell, and prospects for NO-based therapies.

Copyright information

© Current Science Inc 2005

Authors and Affiliations

  • Juan Manuel Encinas
  • Louis Manganas
  • Grigori Enikolopov
    • 1
  1. 1.Cold Spring Harbor LaboratoryCold Spring HarborUSA