Current Neurology and Neuroscience Reports

, Volume 3, Issue 5, pp 373–378

The role of the N-methyl-D-aspartate receptor in Alzheimer’s disease: Therapeutic potential

  • P. Murali Doraiswamy

DOI: 10.1007/s11910-003-0019-8

Cite this article as:
Doraiswamy, P.M. Curr Neurol Neurosci Rep (2003) 3: 373. doi:10.1007/s11910-003-0019-8


Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with an unknown etiology. Pathologic processes implicated in AD include β-amyloid-induced synaptic failure; tau hyperphosphorylation; inflammation; oxidative stress; abnormal neurotransmission involving acetylcholine, glutamate, norepinephrine, serotonin, and dopamine; and abnormalities in second messengers, protein kinases, and apoptosis. Although each of these pathways offers potential therapeutic targets, pharmacologic manipulation of the glutamatergic N-methyl-D-aspartate receptor pathway, alone or in combination with cholinergic therapies, is emerging as the next promising strategy for the treatment of AD and vascular dementia.

Copyright information

© Current Science Inc 2003

Authors and Affiliations

  • P. Murali Doraiswamy
    • 1
  1. 1.Departments of Psychiatry and Medicine, and the Center for the Study of AgingDuke University Medical CenterDurhamUSA