Current Neurology and Neuroscience Reports

, Volume 1, Issue 3, pp 263–270

T cells, cytokines, and autoantigens in multiple sclerosis


  • Bruno Gran
    • Department of NeurologyUniversity of Pennsylvania School of Medicine
  • Abdolmohamad Rostami
    • Department of NeurologyUniversity of Pennsylvania School of Medicine

DOI: 10.1007/s11910-001-0029-3

Cite this article as:
Gran, B. & Rostami, A. Curr Neurol Neurosci Rep (2001) 1: 263. doi:10.1007/s11910-001-0029-3


In multiple sclerosis (MS), inflammatory demyelination in the central nervous system is thought to be initiated by T cells that recognize myelin antigens. T cells are the main regulators of acquired immunity and are involved in the pathogenesis of several organ-specific autoimmune diseases. This review provides an overview of recent studies on the role of T cells in autoimmune demyelination. Because autoreactive T cells are normally present in the mature repertoire of T cells in the blood and lymphoid organs of MS patients, but also in normal controls, particular attention is devoted to the mechanisms of activation and the functional phenotype of such T cells in patients with MS. The role of cytokines as effector molecules and the main candidate antigens are also discussed.

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© Current Science Inc. 2001