The Role of PCR in the Diagnosis of Candida Vulvovaginitis—a New Gold Standard?
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- Sobel, J.D. & Akins, R.A. Curr Infect Dis Rep (2015) 17: 33. doi:10.1007/s11908-015-0488-3
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PCR is recognized as a reliable technique for detection of all types of microorganisms. Being highly objective and reproducible also sensitive and specific, PCR is now widely used for sexually transmitted infection (STI) diagnosis. Potential, however, exists for detecting non-pathogens, and not identifying a pathogenic state decreases specificity or clinical significance. PCR Candida tests of vaginal specimens are now widely available and frequently used offering a modest to moderate increase in sensitivity and are likely to replace traditional culture and DNA homology testing. Nevertheless, there remain considerable gaps in our knowledge regarding the usefulness and applications of these expensive tests.