Current Infectious Disease Reports

, Volume 14, Issue 5, pp 558–565

Septic Arthritis in the Native Joint

Skin, Soft Tissue, Bone, and Joint Infections (N Safdar, Section Editor)

DOI: 10.1007/s11908-012-0285-1

Cite this article as:
Brennan, M.B. & Hsu, J.L. Curr Infect Dis Rep (2012) 14: 558. doi:10.1007/s11908-012-0285-1


Septic arthritis of the native joint is an uncommon infection but, when present, creates a significant risk for functional impairment of the affected joint or, in severe cases, mortality. Knowledge of the most common pathogens, as well as appropriate diagnostics, can facilitate earlier diagnosis and treatment, which, ideally, leads to improved long-term outcomes. In this article, we discuss recent microbiologic trends and diagnostic tests, with an update on use of molecular testing. Empiric antibiotic regimens for native joint septic arthritis are reviewed, as well as potential new therapies on the horizon.


Septic arthritis Infectious arthritis Osteoarticular infection Hot swollen joint Staphylococcus aureus Arthrocentesis Synovial fluid White blood cell count Culture Polymerase chain reaction Antibiotics Joint drainage Dexamethasone Bisphosphonates 

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Division of Infectious DiseaseUniversity of Wisconsin School of Medicine and Public HealthMadisonUSA
  2. 2.Sanford Health Infectious DiseaseSioux FallsUSA
  3. 3.Department of Internal MedicineSanford School of Medicine of the University of South DakotaSioux FallsUSA

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