Current Infectious Disease Reports

, 13:433

Antibiotic Therapy in Neonatal and Pediatric Septic Shock

  • Rajesh K. Aneja
  • Ruby Varughese-Aneja
  • Carol G. Vetterly
  • Joseph A. Carcillo
Article

DOI: 10.1007/s11908-011-0197-5

Cite this article as:
Aneja, R.K., Varughese-Aneja, R., Vetterly, C.G. et al. Curr Infect Dis Rep (2011) 13: 433. doi:10.1007/s11908-011-0197-5
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Abstract

Severe sepsis accounts for nearly 4,500 deaths (mortality rate 10%), and is responsible for nearly $2 billion annual healthcare expenditure in the United States. Early and speedy treatment of critically ill septic patients can halt or reduce the likelihood of physiologic progression to multi-system organ failure. A cornerstone of this therapeutic strategy is antibiotic administration. In this review, we discuss the empirical treatment strategies for the treatment of early and late neonatal sepsis, along with pediatric sepsis. Furthermore, we discuss the rationale that underlies the adoption of such treatment strategies. The present article also discusses the emergence of multi-drug organisms as the causative agents for sepsis, i.e. methicillin-resistant Staphylococcus aureus (MRSA), resistant enterococci and Klebsiella pneumoniae carbapenemases (KPC).

Keywords

Pediatric sepsisNeonatal sepsisSeptic shockAntibioticsMulti-drug resistant organismsAntibiotic therapy

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Rajesh K. Aneja
    • 1
    • 2
    • 5
  • Ruby Varughese-Aneja
    • 3
  • Carol G. Vetterly
    • 4
    • 6
  • Joseph A. Carcillo
    • 1
    • 2
  1. 1.Department of Critical Care MedicineUniversity of Pittsburgh School of Medicine and Children’s Hospital of Pittsburgh of UPMCPittsburghUSA
  2. 2.Department of PediatricsUniversity of Pittsburgh School of Medicine and Children’s Hospital of Pittsburgh of UPMCPittsburghUSA
  3. 3.Division of NeonatologyThe Western Pennsylvania HospitalPittsburghUSA
  4. 4.Department of PharmacyUniversity of Pittsburgh School of Pharmacy and Children’s Hospital of Pittsburgh of UPMCPittsburghUSA
  5. 5.Department of Critical Care MedicineChildren’s Hospital of Pittsburgh of UPMC, Children’s Hospital DrivePittsburghUSA
  6. 6.Department of PharmacyChildren’s Hospital of Pittsburgh of UPMC, Children’s Hospital DrivePittsburghUSA