Update on HHV-8-Associated Malignancies
The human herpesvirus 8 (HHV-8) is the oncogenic virus associated with Kaposi’s sarcoma (KS) and lymphoproliferative disorders, namely, primary effusion lymphoma and multicentric Castleman’s disease. KS is among the most common malignancies seen in HIV-infected patients despite the decreased incidence of KS in the era of highly active antiretroviral therapy. Advances in molecular pathology reveal HHV-8 tumorigenesis is mediated through molecular mimicry wherein viral-encoded proteins can activate several cellular signaling cascades while evading immune surveillance. This knowledge has led to the evolution of multiple therapeutic strategies against specific molecular targets. Many such therapeutic modalities have shown activity, but none have proven to be curative. Identifying possible prognostic factors is another active area of research. This review summarizes the recent developments in the fields of virus transmission, molecular biology, and treatment of HHV-8-related neoplasms.
- Update on HHV-8-Associated Malignancies
- Open Access
- Available under Open Access This content is freely available online to anyone, anywhere at any time.
Current Infectious Disease Reports
Volume 12, Issue 2 , pp 147-154
- Cover Date
- Print ISSN
- Online ISSN
- Current Science Inc.
- Additional Links
- Human herpesvirus 8
- Kaposi's sarcoma
- Primary effusion lymphoma
- Multicentric Castleman's disease
- Industry Sectors
- Author Affiliations
- 1. Department of Hematology/Medical Oncology, Winship Cancer Institute, Emory University, Room 2054, 1365C Clifton Road, Atlanta, GA, 30322, USA
- 2. Hematology/Oncology, Moores Cancer Center, University of California, San Diego, 3855 Health Sciences, MC #0987 La Jolla, CA, USA