The prospect of vaccination against group a β-hemolytic streptococci
- First Online:
- Cite this article as:
- Kotloff, K.L. Curr Infect Dis Rep (2008) 10: 192. doi:10.1007/s11908-008-0032-9
- 40 Downloads
Group A streptococcus is a widespread human pathogen that causes a broad spectrum of human disease. The persistent high burden and severity of illness in developing and industrialized countries speaks to the need for a safe and effective vaccine. Modern approaches to vaccine construction include M protein type-specific vaccines, vaccines utilizing conserved M antigens, and vaccines based on other conserved surface-expressed or secreted antigens. Vaccine candidates in various stages of development offer promise for prevention of Group A streptococcal infections and their sequelae.