Current Infectious Disease Reports

, Volume 10, Issue 3, pp 192–199

The prospect of vaccination against group a β-hemolytic streptococci


DOI: 10.1007/s11908-008-0032-9

Cite this article as:
Kotloff, K.L. Curr Infect Dis Rep (2008) 10: 192. doi:10.1007/s11908-008-0032-9


Group A streptococcus is a widespread human pathogen that causes a broad spectrum of human disease. The persistent high burden and severity of illness in developing and industrialized countries speaks to the need for a safe and effective vaccine. Modern approaches to vaccine construction include M protein type-specific vaccines, vaccines utilizing conserved M antigens, and vaccines based on other conserved surface-expressed or secreted antigens. Vaccine candidates in various stages of development offer promise for prevention of Group A streptococcal infections and their sequelae.

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© Current Medicine Group LLC 2008

Authors and Affiliations

  1. 1.Division of Infectious Disease and Tropical Pediatrics, Department of Pediatrics, Division of Geographic Medicine, Department of Medicine, Center for Vaccine DevelopmentUniversity of Maryland School of MedicineBaltimoreUSA