New horizons for the infectious diseases specialist: How gut microflora promote health and disease
- Shervin Rabizadeh
- , Cynthia SearsAffiliated withDivision of Infectious Disease and Gastroenterology, Department of Oncology and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine; and Department of Medicine Email author
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The human intestine provides an expansive interface for interactions with the microflora. Increasing data support the hypothesis that host-microflora relationships are markedly dynamic, contributing to host health and disease pathogenesis. Despite outnumbering human cells 10-fold, the microflora most often assist the host through symbiotic relationships. The microflora are involved in maximizing host utilization of nutrients, induction of host immune responses, and promotion of intestinal cell and mucosal development. However, evolving data suggest that disturbances in this symbiotic relationship can lead the microflora to be pathogenic in diverse conditions such as inflammatory bowel disease, irritable bowel disease, obesity, graft-versus-host disease, HIV immunopathogenesis, and possibly cancer. Defining those microflora attributes that result in health and those that trigger disease is key to harnessing the microflora to promote human health.
- New horizons for the infectious diseases specialist: How gut microflora promote health and disease
Current Infectious Disease Reports
Volume 10, Issue 2 , pp 92-98
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- Current Science Inc.
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- 1. Division of Infectious Disease and Gastroenterology, Department of Oncology and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine; and Department of Medicine, 1550 Orleans Street, CRB 2 Building, Suite 1M-05, Baltimore, MD, 21287, USA