Current Infectious Disease Reports

, Volume 10, Issue 1, pp 74–81

Liver transplant in patients with HIV: Infection risk associated with HIV and post-transplant immunosuppression

  • Pierluigi Viale
  • Umberto Baccarani
  • Marcello Tavio
Article

DOI: 10.1007/s11908-008-0013-z

Cite this article as:
Viale, P., Baccarani, U. & Tavio, M. Curr Infect Dis Rep (2008) 10: 74. doi:10.1007/s11908-008-0013-z
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Abstract

Before the introduction of highly active antiretroviral therapy, HIV-infected patients who underwent liver transplantation (LT) had poor survival, mainly because of a rapid progression to AIDS and its infectious complications during the post-LT immunosuppression phase. However, in the era of highly active antiretroviral therapy, under some specific and well-determined conditions, LT might be as safe and efficacious in HIV patients as it is in non-HIV-infected patients. End-stage liver failure as caused by hepatitis B virus, cirrhosis, and hepatotoxicity should be considered indications for LT in every transplant center. Because of the almost universal hepatitis C virus reinfection and its accelerated course post-LT, LT in hepatitis C virus-coinfected patients deserves more caution and more extended follow-up before it is accepted as a standard indication for LT in HIV-infected patients.

Copyright information

© Current Medicine Group LLC 2008

Authors and Affiliations

  • Pierluigi Viale
  • Umberto Baccarani
  • Marcello Tavio
    • 1
  1. 1.Azienda Ospedaliero-Universitaria di UdineUdineItaly

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