Current Infectious Disease Reports

, Volume 8, Issue 6, pp 449–456

Recent insights into the mechanisms of antifungal resistance

Article

DOI: 10.1007/s11908-006-0019-3

Cite this article as:
Barker, K.S. & Rogers, P.D. Curr Infect Dis Rep (2006) 8: 449. doi:10.1007/s11908-006-0019-3

Abstract

The incidence of fungal infections has increased in recent years, particularly among immunocompromised individuals. Treatment of invasive fungal infections has been hampered by a limited number of available antifungal agents and both intrinsic and acquired resistance to these agents among many fungal pathogens. Therefore, much interest has focused on elucidating the molecular basis for antifungal resistance. Recent efforts have increased our understanding of this process, including the transcriptional regulation of azole resistance in Candida spp, mechanisms of intrinsic resistance to amphotericin B, and mechanisms of acquired resistance to the new echinocandin class of antifungal agents. This review discusses these and other newly clarified resistance mechanisms, as well as the direction of future antifungal resistance research. Despite these advances, undiscovered resistance determinants exist, and resistance to newer agents likely will continue to emerge.

Copyright information

© Current Science Inc 2006

Authors and Affiliations

  1. 1.Room 304 West Patient TowerLeBonheur Children’s Medical CenterMemphisUSA