Current Hypertension Reports

, 16:420

ACE2: Angiotensin II/Angiotensin-(1–7) Balance in Cardiac and Renal Injury

  • Jasmina Varagic
  • Sarfaraz Ahmad
  • Sayaka Nagata
  • Carlos M. Ferrario
Mediators, Mechanisms, and Pathways in Tissue Injury (T Fujita, Section Editor)

DOI: 10.1007/s11906-014-0420-5

Cite this article as:
Varagic, J., Ahmad, S., Nagata, S. et al. Curr Hypertens Rep (2014) 16: 420. doi:10.1007/s11906-014-0420-5
Part of the following topical collections:
  1. Topical Collection on Hypertension and Metabolic Syndrome

Abstract

Our current recognition of the renin-angiotensin system is more convoluted than originally thought due to the discovery of multiple novel enzymes, peptides, and receptors inherent in this interactive biochemical cascade. Over the last decade, angiotensin-converting enzyme 2 (ACE2) has emerged as a key player in the pathophysiology of hypertension and cardiovascular and renal disease due to its pivotal role in metabolizing vasoconstrictive/hypertrophic/proliferative angiotensin II into favorable angiotensin-(1–7). This review addresses the considerable advancement in research on the role of tissue ACE2 in the development and progression of hypertension and cardiac and renal injury. We summarize the results from recent clinical and experimental studies suggesting that serum or urine soluble ACE2 may serve as a novel biomarker or independent risk factor relevant for diagnosis and prognosis of cardiorenal disease. We also review recent proceedings on novel therapeutic approaches to enhance ACE2/angiotensin-(1–7) axis.

Keywords

Angiotensin-converting enzyme 2Angiotensin IIAngiotensin-(1–7)HeartKidneyHypertensionLeft ventricular remodelingHeart failureDiabetesRenal disease

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Jasmina Varagic
    • 1
    • 2
    • 3
  • Sarfaraz Ahmad
    • 2
  • Sayaka Nagata
    • 2
  • Carlos M. Ferrario
    • 2
    • 3
    • 4
  1. 1.Hypertension & Vascular Research Center, Division of Surgical SciencesWake Forest University School of MedicineWinston-SalemUSA
  2. 2.Division of Surgical SciencesWake Forest University School of MedicineWinston-SalemUSA
  3. 3.Department of Physiology and PharmacologyWake Forest University School of MedicineWinston-SalemUSA
  4. 4.Department of Internal Medicine and NephrologyWake Forest University School of MedicineWinston-SalemUSA