Current Hypertension Reports

, Volume 15, Issue 4, pp 370–376

The Sympathetic Nervous System in Chronic Kidney Disease

  • Sebastian Ewen
  • Christian Ukena
  • Dominik Linz
  • Roland E. Schmieder
  • Michael Böhm
  • Felix Mahfoud
Secondary Hypertension: Adrenal and Nervous System Mechanisms (S Oparil, Section Editor)

DOI: 10.1007/s11906-013-0365-0

Cite this article as:
Ewen, S., Ukena, C., Linz, D. et al. Curr Hypertens Rep (2013) 15: 370. doi:10.1007/s11906-013-0365-0

Abstract

Accumulating evidence has shown that the sympathetic nervous system plays an important role in the pathophysiology and progression of several chronic disorders, e.g., arterial hypertension, cardiac arrhythmias, heart failure, and in particular chronic kidney disease (CKD). Experimental and clinical studies provide evidence that sympathetic inhibition using either sympatholytic pharmacotherapy or catheter-based renal denervation has beneficial effects in patients with CKD. Randomized clinical trials are needed to characterize the underlying pathophysiological mechanisms, and systematically evaluate the therapeutic effects of sympathetic inhibition in this high-risk patient population. In this review current knowledge of the role of the sympathetic nervous system in the development and progression of CKD will be summarized, and novel treatment options targeting sympathetic nervous system activity will be discussed.

Keywords

HypertensionChronic renal failureCKDSympathetic nervous systemSympathetic overdriveRenal injuryIschemiaNitric oxideNOAsymmetric dimethlyarginine (ADMA)-related mechanismsOxidative stressAng IIRenalasePharmacotherapyRenal denervationDialysisHypertension

List of abbreviations

ACE

angiotensin-converting enzyme

ADMA

asymmetric dimethlyarginine

Ang II

angiotensin II

ARB

angiotensin receptor blocker

BP

blood pressure

CKD

chronic kidney disease

ESRD

end-stage renal disease

GFR

glomerular filtration rate

MSNA

muscle sympathetic nerve activity

NE

norepinephrine

NO

nitric oxide

NOS

nitric oxide synthase

RAAS

renin-angiotensin-aldosterone system

SNS

sympathetic nervous system.

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Sebastian Ewen
    • 1
  • Christian Ukena
    • 1
  • Dominik Linz
    • 1
  • Roland E. Schmieder
    • 2
  • Michael Böhm
    • 1
  • Felix Mahfoud
    • 1
  1. 1.Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische IntensivmedizinUniversitätsklinikum des SaarlandesHomburg/SaarGermany
  2. 2.Medizinische Klinik 4, Nephrologie und HypertensiologieUniversitätsklinikum ErlangenErlangenGermany