Current Hypertension Reports

, Volume 15, Issue 1, pp 47–58

Pathophysiology of Hypertension in the Absence of Nitric Oxide/Cyclic GMP Signaling

  • Robrecht Thoonen
  • Patrick Y. Sips
  • Kenneth D. Bloch
  • Emmanuel S. Buys
Hypertension and the Kidney (RM Carey and A Mimran, Section Editors)

DOI: 10.1007/s11906-012-0320-5

Cite this article as:
Thoonen, R., Sips, P.Y., Bloch, K.D. et al. Curr Hypertens Rep (2013) 15: 47. doi:10.1007/s11906-012-0320-5

Abstract

The nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling system is a well-characterized modulator of cardiovascular function, in general, and blood pressure, in particular. The availability of mice mutant for key enzymes in the NO-cGMP signaling system facilitated the identification of interactions with other blood pressure modifying pathways (e.g. the renin-angiotensin-aldosterone system) and of gender-specific effects of impaired NO-cGMP signaling. In addition, recent genome-wide association studies identified blood pressure-modifying genetic variants in genes that modulate NO and cGMP levels. Together, these findings have advanced our understanding of how NO-cGMP signaling regulates blood pressure. In this review, we will summarize the results obtained in mice with disrupted NO-cGMP signaling and highlight the relevance of this pathway as a potential therapeutic target for the treatment of hypertension.

Keywords

Cyclic guanosine monophosphateBlood pressureHypertensionCardiovascular functionSoluble guanylate cyclaseNitric oxideMutant miceGenetic variantsRenin-angiotensin-aldosterone signalingGenderS-nitrosylationTherapeutics

Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Robrecht Thoonen
    • 1
  • Patrick Y. Sips
    • 2
  • Kenneth D. Bloch
    • 3
  • Emmanuel S. Buys
    • 4
  1. 1.Molecular Cardiology Research Institute, Molecular Cardiology Research CenterTufts Medical CenterBostonUSA
  2. 2.Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General HospitalHarvard Medical SchoolCharlestownUSA
  3. 3.Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical SchoolBostonUSA
  4. 4.Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General HospitalHarvard Medical SchoolBostonUSA