, Volume 14, Issue 5, pp 403-409
Date: 27 Jul 2012

Impact of the AT2 Receptor Agonist C21 on Blood Pressure and Beyond

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Abstract

It is now widely accepted that the angiotensin AT2 receptor (AT2R) plays an important protective role during pathophysiologic conditions, acting as a repair system. The development of the first selective nonpeptide AT2R agonist C21 accelerated our understanding of AT2R-mediated protective signaling and actions. This article reviews the impact of C21 on blood pressure in normotensive and hypertensive animal models. Although C21 does not act as a classical antihypertensive drug, it could be useful in preventing hypertension-induced vascular and other end organ damages via anti-apoptotic, anti-fibrotic and anti-inflammatory actions. In particular, a strong body of evidence started to emerge around its anti-inflammatory feature. This property should be further investigated for potential clinical indications in cardiovascular diseases and beyond.