The Therapeutic Trials (G Mancia and TD Giles, Section Editors)

Current Hypertension Reports

, Volume 14, Issue 4, pp 333-338

First online:

Total Cardiovascular Risk, Blood Pressure Variability and Adrenergic Overdrive in Hypertension: Evidence, Mechanisms and Clinical Implications

  • Guido GrassiAffiliated withClinica Medica, Ospedale San Gerardo dei Tintori Monza, University of Milano-BicoccaIstituto Scientifico Multimedica, Sesto San GiovanniClinica Medica, Ospedale S Gerardo Email author 
  • , Michele BombelliAffiliated withClinica Medica, Ospedale San Gerardo dei Tintori Monza, University of Milano-Bicocca
  • , Gianmaria BrambillaAffiliated withClinica Medica, Ospedale San Gerardo dei Tintori Monza, University of Milano-Bicocca
  • , Fosca Quarti TrevanoAffiliated withClinica Medica, Ospedale San Gerardo dei Tintori Monza, University of Milano-Bicocca
  • , Raffaella Dell’OroAffiliated withClinica Medica, Ospedale San Gerardo dei Tintori Monza, University of Milano-Bicocca
  • , Giuseppe ManciaAffiliated withClinica Medica, Ospedale San Gerardo dei Tintori Monza, University of Milano-Bicocca

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Abstract

In hypertensive patients the risk of developing cardiovascular events and complications depends not only on the magnitude of the blood pressure elevation, but also, and to a consistent extent, on the presence of associated cardiovascular risk factors, concomitant disease and target organ damage. Recent findings suggest that also sympathetic overdrive and alterations in blood pressure variability (which are detected in hypertension) may participate at the increased cardiovascular risk of the patients with high blood pressure. This review will discuss the evidence collected over the past few years on the relationships between sympathetic activation and blood pressure variability and their impact on cardiovascular risk profile.

Keywords

Cardiovascular risk Hypertension Sympathetic nervous system Blood pressure variability Ambulatory blood pressure monitoring Cardiovascular risk factors