Current Hypertension Reports

, Volume 14, Issue 4, pp 333–338

Total Cardiovascular Risk, Blood Pressure Variability and Adrenergic Overdrive in Hypertension: Evidence, Mechanisms and Clinical Implications

Authors

    • Clinica Medica, Ospedale San Gerardo dei Tintori MonzaUniversity of Milano-Bicocca
    • Istituto Scientifico MultimedicaSesto San Giovanni
    • Clinica Medica, Ospedale S Gerardo
  • Michele Bombelli
    • Clinica Medica, Ospedale San Gerardo dei Tintori MonzaUniversity of Milano-Bicocca
  • Gianmaria Brambilla
    • Clinica Medica, Ospedale San Gerardo dei Tintori MonzaUniversity of Milano-Bicocca
  • Fosca Quarti Trevano
    • Clinica Medica, Ospedale San Gerardo dei Tintori MonzaUniversity of Milano-Bicocca
  • Raffaella Dell’Oro
    • Clinica Medica, Ospedale San Gerardo dei Tintori MonzaUniversity of Milano-Bicocca
  • Giuseppe Mancia
    • Clinica Medica, Ospedale San Gerardo dei Tintori MonzaUniversity of Milano-Bicocca
The Therapeutic Trials (G Mancia and TD Giles, Section Editors)

DOI: 10.1007/s11906-012-0273-8

Cite this article as:
Grassi, G., Bombelli, M., Brambilla, G. et al. Curr Hypertens Rep (2012) 14: 333. doi:10.1007/s11906-012-0273-8

Abstract

In hypertensive patients the risk of developing cardiovascular events and complications depends not only on the magnitude of the blood pressure elevation, but also, and to a consistent extent, on the presence of associated cardiovascular risk factors, concomitant disease and target organ damage. Recent findings suggest that also sympathetic overdrive and alterations in blood pressure variability (which are detected in hypertension) may participate at the increased cardiovascular risk of the patients with high blood pressure. This review will discuss the evidence collected over the past few years on the relationships between sympathetic activation and blood pressure variability and their impact on cardiovascular risk profile.

Keywords

Cardiovascular riskHypertensionSympathetic nervous systemBlood pressure variabilityAmbulatory blood pressure monitoringCardiovascular risk factors

Copyright information

© Springer Science+Business Media, LLC 2012