Current Hypertension Reports

, Volume 14, Issue 1, pp 70–78

The Nox Family of NADPH Oxidases: Friend or Foe of the Vascular System?

Vascular Mechanisms (F Ruschitzka, Section Editor)

DOI: 10.1007/s11906-011-0238-3

Cite this article as:
Takac, I., Schröder, K. & Brandes, R.P. Curr Hypertens Rep (2012) 14: 70. doi:10.1007/s11906-011-0238-3

Abstract

NADPH (nicotinamide adenine dinucleotide phosphate) oxidases are important sources of reactive oxygen species (ROS). In the vascular system, ROS can have both beneficial and detrimental effects. Under physiologic conditions, ROS are involved in signaling pathways that regulate vascular tone as well as cellular processes like proliferation, migration and differentiation. However, high doses of ROS, which are produced after induction or activation of NADPH oxidases in response to cardiovascular risk factors and inflammation, contribute to the development of endothelial dysfunction and vascular disease. In vascular cells, the NADPH oxidase isoforms Nox1, Nox2, Nox4, and Nox5 are expressed, which differ in their activity, response to stimuli, and the type of ROS released. This review focuses on the specific role of different NADPH oxidase isoforms in vascular physiology and their potential contributions to vascular diseases.

Keywords

NADPH oxidase Reactive oxygen species Endothelial dysfunction Vascular tone Hypertension Arteriosclerosis Angiogenesis Endothelium Nitric oxide Nox proteins 

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Institut für Kardiovaskuläre PhysiologieFachbereich Medizin der Goethe-UniversitätFrankfurt am MainGermany

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