Current Hypertension Reports

, Volume 13, Issue 2, pp 103–108

Hypertension Due to Loss of Clock: Novel Insight From the Molecular Analysis of Cry1/Cry2–Deleted Mice

  • Hitoshi Okamura
  • Masao Doi
  • Yoshiaki Yamaguchi
  • Jean-Michel Fustin
Article

DOI: 10.1007/s11906-011-0181-3

Cite this article as:
Okamura, H., Doi, M., Yamaguchi, Y. et al. Curr Hypertens Rep (2011) 13: 103. doi:10.1007/s11906-011-0181-3

Abstract

In our consumer-oriented society, in which productivity requires around-the-clock activity and demanding shift work, the biologic system that regulates our internal rhythms is being compromised. Poor sleep patterns and hectic lifestyle are detrimental to harmonious physiological and metabolic body systems, with severe impact on public health. Over a trillion peripheral cellular clocks throughout the body, supervised by the master clock located in the hypothalamic suprachiasmatic nucleus, govern most aspects of physiology and behavior. To exemplify the importance of the biologic clock for health, we have recently demonstrated that mice that are arrhythmic because of the deletion of Cry1 and Cry2 clock genes suffer from salt-sensitive hypertension. In these mice, a novel 3β-hydroxyl-steroid dehydrogenase (3β–Hsd) gene under clock control is severely overexpressed specifically in aldosterone-producing cells in the adrenal cortex, leading to hyperaldosteronism and ultimately to salt-sensitive hypertension. The human homologue of this aldosterone-producing, cell-specific enzyme was also characterized and represents a new possibility in the pathogenesis of hypertension.

Keywords

Clock genesCircadian rhythmSuprachiasmatic nucleusPeripheral clockClock-controlled genesPrimary aldosteronismHypertension

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Hitoshi Okamura
    • 1
  • Masao Doi
    • 1
  • Yoshiaki Yamaguchi
    • 1
  • Jean-Michel Fustin
    • 1
  1. 1.Department of Systems Biology, School of Pharmaceutical ScienceKyoto UniversityKyotoJapan