Current Hypertension Reports

, Volume 12, Issue 4, pp 296–302

New Therapeutic Approaches to Resistant Hypertension

  • Markus P. Schlaich
  • Henry Krum
  • Murray D. Esler
Article

DOI: 10.1007/s11906-010-0119-1

Cite this article as:
Schlaich, M.P., Krum, H. & Esler, M.D. Curr Hypertens Rep (2010) 12: 296. doi:10.1007/s11906-010-0119-1

Abstract

Resistant hypertension is a common and growing clinical problem characterized by failure to achieve target blood pressure levels despite adequate use of at least three antihypertensive agents. Although numerous safe and effective pharmacologic therapies are available to treat elevated blood pressure, novel therapeutic approaches are warranted to improve the management and prognosis of patients with resistant hypertension. In this context, several lines of research have generated promising results based on both novel pharmacologic and device-based approaches that may more effectively treat resistant hypertension and its adverse consequences in the future.

Keywords

Resistant hypertension Therapy Renin Aldosterone Sympathetic Renal nerves Baroreflex 

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Markus P. Schlaich
    • 1
  • Henry Krum
    • 2
  • Murray D. Esler
    • 1
  1. 1.Neurovascular Hypertension & Kidney Disease LaboratoryBaker IDI Heart & Diabetes InstituteMelbourneAustralia
  2. 2.Monash Centre of Cardiovascular Research & Education in Therapeutics, School of Public Health and Preventive Medicine, Monash UniversityMelbourneAustralia