Current Hypertension Reports

, Volume 10, Issue 2, pp 156–164

The link between abdominal obesity and the metabolic syndrome

Article

DOI: 10.1007/s11906-008-0029-7

Cite this article as:
Phillips, L.K. & Prins, J.B. Current Science Inc (2008) 10: 156. doi:10.1007/s11906-008-0029-7

Abstract

The clustering of cardiovascular risk factors associated with abdominal obesity is well established. Although currently lacking a universal definition, the metabolic syndrome describes a constellation of metabolic abnormalities, including abdominal obesity, and was originally introduced to characterize a population at high cardiovascular risk. Adipose tissue is a dynamic endocrine organ that secretes several inflammatory and immune mediators known as adipokines. Dysregulation of adipokine secretion, free fatty acid toxicity, and the site-specific differences in abdominal (visceral) versus subcutaneous fat support abdominal obesity as a causal factor mediating the insulin resistance, increased risk of diabetes, and cardiovascular disease in the metabolic syndrome.

Copyright information

© Current Medicine Group LLC 2008

Authors and Affiliations

  1. 1.Diamantina Institute for Cancer, Immunology, and Metabolic MedicineUniversity of Queensland, Princess Alexandra HospitalWoolloongabbaAustralia