Current Hypertension Reports

, Volume 9, Issue 3, pp 184–189

Compliance and fixed-dose combination therapy

  • Sripal Bangalore
  • Anupama Shahane
  • Sanobar Parkar
  • Franz H. Messerli
Article

DOI: 10.1007/s11906-007-0033-3

Cite this article as:
Bangalore, S., Shahane, A., Parkar, S. et al. Current Science Inc (2007) 9: 184. doi:10.1007/s11906-007-0033-3

Abstract

Despite data on the importance of blood pressure control in preventing cardiovascular and cerebrovascular events, only 34% of hypertensive patients have their blood pressure under control. The National Council on Patient Information and Education has estimated that the compliance rate is just over 30% for chronic conditions like hypertension. Polypharmacy and complex treatment regimens have been identified as important, modifiable risk factors for medication noncompliance. Fixed-dose combination regimens are attractive options because of the improved antihypertensive efficacy resulting from the dual mechanistic action of components targeting different effector mechanisms. One drug in the fixed-dose combination may negate an adverse effect of the other medication. Above all, fixed-dose combination therapy reduces pill burden and improves medication compliance, which can translate into better cardiovascular outcomes. Fixed-dose combinations should be used routinely for the management of hypertension and should also be considered when initiating therapy for patients with newly diagnosed hypertension.

Copyright information

© Current Medicine Group LLC 2007

Authors and Affiliations

  • Sripal Bangalore
  • Anupama Shahane
  • Sanobar Parkar
  • Franz H. Messerli
    • 1
  1. 1.Hypertension Program, Division of Cardiology, ColumbiaUniversity College of Physicians and Surgeons, St. Luke’s-Roosevelt Hospital CenterNew YorkUSA

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