Current Hypertension Reports

, Volume 9, Issue 3, pp 184-189

Compliance and fixed-dose combination therapy

  • Sripal Bangalore
  • , Anupama Shahane
  • , Sanobar Parkar
  • , Franz H. MesserliAffiliated withHypertension Program, Division of Cardiology, Columbia, University College of Physicians and Surgeons, St. Luke’s-Roosevelt Hospital Center Email author 

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Despite data on the importance of blood pressure control in preventing cardiovascular and cerebrovascular events, only 34% of hypertensive patients have their blood pressure under control. The National Council on Patient Information and Education has estimated that the compliance rate is just over 30% for chronic conditions like hypertension. Polypharmacy and complex treatment regimens have been identified as important, modifiable risk factors for medication noncompliance. Fixed-dose combination regimens are attractive options because of the improved antihypertensive efficacy resulting from the dual mechanistic action of components targeting different effector mechanisms. One drug in the fixed-dose combination may negate an adverse effect of the other medication. Above all, fixed-dose combination therapy reduces pill burden and improves medication compliance, which can translate into better cardiovascular outcomes. Fixed-dose combinations should be used routinely for the management of hypertension and should also be considered when initiating therapy for patients with newly diagnosed hypertension.