Current HIV/AIDS Reports

, Volume 11, Issue 1, pp 1–10

Are Infants Unique in Their Ability to be “Functionally Cured” of HIV-1?

HIV Pathogenesis and Treatment (AL Landay, Section Editor)

DOI: 10.1007/s11904-013-0189-1

Cite this article as:
Tobin, N.H. & Aldrovandi, G.M. Curr HIV/AIDS Rep (2014) 11: 1. doi:10.1007/s11904-013-0189-1


The recent report of an infant that appears to have achieved a “functional cure” of HIV-1 following receipt of antiretroviral therapy (ART) within 30 hours of birth raises many questions: was the child infected? Was this result due to unique features of this particular infant’s immune system, the immune system of infants or the very early initiation of effective ART? In this manuscript, we discuss the pathogenesis of HIV-1 in infants, highlighting the unique features of infant immune development and how these may inform efforts to cure HIV infection. We will also compare the path to infant “cure” to cures in adults.


HIVMother-to-child transmission (MTCT)NeonateInfantPathogenesisCureCD4+ T cellsCD8+ T cellsCentral memory T cells (TCM)Effector memory T cells (TEM)ReservoirImmune quiescenceImmune toleranceMicrobial translocationFunctional cureHIV-1Antiretroviral therapy (ART)HIV pathogenesis

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of PediatricsChildren’s Hospital Los AngelesLos AngelesUSA
  2. 2.Department of Pediatrics, Children’s Hospital Los AngelesThe Saban Research Institute, University of Southern CaliforniaLos AngelesUSA