Current HIV/AIDS Reports

, Volume 10, Issue 2, pp 124–133

Antiretroviral Drug Regimens to Prevent Mother-To-Child Transmission of HIV: A Review of Scientific, Program, and Policy Advances for Sub-Saharan Africa

  • Benjamin H. Chi
  • Jeffrey S. A. Stringer
  • Dhayendre Moodley
The Global Epidemic (Q Abdool Karim, Section Editor)

DOI: 10.1007/s11904-013-0154-z

Cite this article as:
Chi, B.H., Stringer, J.S.A. & Moodley, D. Curr HIV/AIDS Rep (2013) 10: 124. doi:10.1007/s11904-013-0154-z

Abstract

Considerable advances have been made in the effort to prevent mother-to-child HIV transmission (PMTCT) in sub-Saharan Africa. Clinical trials have demonstrated the efficacy of antiretroviral regimens to interrupt HIV transmission through the antenatal, intrapartum, and postnatal periods. Scientific discoveries have been rapidly translated into health policy, bolstered by substantial investment in health infrastructure capable of delivering increasingly complex services. A new scientific agenda is also emerging, one that is focused on the challenges of effective and sustainable program implementation. Finally, global campaigns to “virtually eliminate” pediatric HIV and dramatically reduce HIV-related maternal mortality have mobilized new resources and renewed political will. Each of these developments marks a major step in regional PMTCT efforts; their convergence signals a time of rapid progress in the field, characterized by an increased interdependency between clinical research, program implementation, and policy. In this review, we take stock of recent advances across each of these areas, highlighting the challenges—and opportunities—of improving health services for HIV-infected mothers and their children across the region.

Keywords

Prevention of mother-to-child HIV transmission PMTCT HIV Antiretroviral prophylaxis Sub-Saharan Africa Global epidemic 

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Benjamin H. Chi
    • 1
    • 2
  • Jeffrey S. A. Stringer
    • 1
    • 2
  • Dhayendre Moodley
    • 3
  1. 1.Centre for Infectious Disease Research in Zambia (CIDRZ)LusakaZambia
  2. 2.University of North Carolina at Chapel HillChapel HillUSA
  3. 3.Centre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R. Mandela School of MedicineUniversity of KwaZulu-NatalDurbanSouth Africa