Current HIV/AIDS Reports

, Volume 9, Issue 2, pp 160–170

HIV-1 Prevention for HIV-1 Serodiscordant Couples

  • Kathryn Curran
  • Jared M. Baeten
  • Thomas J. Coates
  • Ann Kurth
  • Nelly R. Mugo
  • Connie Celum
Antiretroviral Therapies (A Pozniak, Section Editor)

DOI: 10.1007/s11904-012-0114-z

Cite this article as:
Curran, K., Baeten, J.M., Coates, T.J. et al. Curr HIV/AIDS Rep (2012) 9: 160. doi:10.1007/s11904-012-0114-z

Abstract

A substantial proportion of HIV-1 infected individuals in sub-Saharan Africa are in stable relationships with HIV-1 uninfected partners, and HIV-1 serodiscordant couples thus represent an important target population for HIV-1 prevention. Couple-based HIV-1 testing and counseling facilitates identification of HIV-1 serodiscordant couples, counseling about risk reduction, and referrals to HIV-1 treatment, reproductive health services, and support services. Maximizing HIV-1 prevention for HIV-1 serodiscordant couples requires a combination of strategies, including counseling about condoms, sexual risk, fertility, contraception, and the clinical and prevention benefits of antiretroviral therapy (ART) for the HIV-1-infected partner; provision of clinical care and ART for the HIV-1-infected partner; antenatal care and services to prevent mother-to-child transmission for HIV-1-infected pregnant women; male circumcision for HIV-1-uninfected men; and, pending guidelines and demonstration projects, oral pre-exposure prophylaxis (PrEP) for HIV-1-uninfected partners.

Keywords

HIV-1 serodiscordant couples HIV-1 prevention Africa Antiretroviral ART PrEP 

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Kathryn Curran
    • 1
  • Jared M. Baeten
    • 1
  • Thomas J. Coates
    • 2
  • Ann Kurth
    • 3
  • Nelly R. Mugo
    • 4
  • Connie Celum
    • 1
  1. 1.International Clinical Research Center, Department of Global HealthUniversity of Washington, Box 359927SeattleUSA
  2. 2.Division of Infectious Diseases and Program in Global Health, David Geffen School of MedicineUniversity of CaliforniaLos AngelesUSA
  3. 3.New York University College of NursingNew YorkUSA
  4. 4.University of Nairobi Institute of Tropical and Infectious Diseases (UNITID), Kenyatta National HospitalNairobiKenya

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