Current HIV/AIDS Reports

, Volume 9, Issue 1, pp 5–15

HIV Reservoirs and Strategies for Eradication

  • Miranda Z. Smith
  • Fiona Wightman
  • Sharon R. Lewin
The Science of HIV (AL Landay, Section Editor)

DOI: 10.1007/s11904-011-0108-2

Cite this article as:
Smith, M.Z., Wightman, F. & Lewin, S.R. Curr HIV/AIDS Rep (2012) 9: 5. doi:10.1007/s11904-011-0108-2

Abstract

Combination antiretroviral therapy (cART) has led to a reduction in morbidity and mortality in HIV-infected patients but therapy is lifelong and there is no cure for HIV. The major barriers to cure include HIV latency, which has been identified in different T-cell subsets, as well as persistence of HIV in anatomical reservoirs. We review recent developments in our understanding of the major reservoirs of HIV in patients on cART as well as how latency is established and maintained in T cells. Finally, we review the scientific rationale of and clinical experience with pharmacotherapeutic strategies aimed at eliminating latently infected cells.

Keywords

LatencyReservoirsViremiaEradicationCD4+ T cellsTissueGastrointestinal tractActivationAntiretroviral treatment

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Miranda Z. Smith
    • 1
    • 2
  • Fiona Wightman
    • 1
    • 2
  • Sharon R. Lewin
    • 1
    • 2
    • 3
  1. 1.Department of Medicine, Central Clinical SchoolMonash UniversityMelbourneAustralia
  2. 2.Centre for VirologyBurnet InstituteMelbourneAustralia
  3. 3.Infectious Diseases UnitAlfred HospitalMelbourneAustralia