The Science of HIV (AL Landay, Section Editor)

Current HIV/AIDS Reports

, Volume 9, Issue 1, pp 5-15

First online:

HIV Reservoirs and Strategies for Eradication

  • Miranda Z. SmithAffiliated withDepartment of Medicine, Central Clinical School, Monash UniversityCentre for Virology, Burnet Institute
  • , Fiona WightmanAffiliated withDepartment of Medicine, Central Clinical School, Monash UniversityCentre for Virology, Burnet Institute
  • , Sharon R. LewinAffiliated withDepartment of Medicine, Central Clinical School, Monash UniversityCentre for Virology, Burnet InstituteInfectious Diseases Unit, Alfred Hospital Email author 

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Abstract

Combination antiretroviral therapy (cART) has led to a reduction in morbidity and mortality in HIV-infected patients but therapy is lifelong and there is no cure for HIV. The major barriers to cure include HIV latency, which has been identified in different T-cell subsets, as well as persistence of HIV in anatomical reservoirs. We review recent developments in our understanding of the major reservoirs of HIV in patients on cART as well as how latency is established and maintained in T cells. Finally, we review the scientific rationale of and clinical experience with pharmacotherapeutic strategies aimed at eliminating latently infected cells.

Keywords

Latency Reservoirs Viremia Eradication CD4+ T cells Tissue Gastrointestinal tract Activation Antiretroviral treatment